Spider-web hierarchy can be introduced by adding smaller hexagons at the centers of original cells in an underlying hexagonal network and connecting the adjacent vertices by straight beams. To examine the out-of-plane crashworthiness of this new type of hierarchical honeycomb concept, a finite element model is established and validated by existing theoretical and experimental results. Then, a parametric study on structural variables [Formula: see text] and [Formula: see text] was carried out with three different densities. The mechanical properties of hierarchical honeycombs are also compared with that of regular honeycombs. The research results show that the deformation patterns of hierarchical honeycombs can be divided into three categories. The energy absorption capability can be controlled effectively by proper adjustment of the hierarchical structural parameters. The specific energy absorption per unit mass ([Formula: see text]) of first-order spider-web hierarchical honeycomb with [Formula: see text] and second-order spider-web hierarchical honeycomb with [Formula: see text] and [Formula: see text] increases by 62.1% and 82.4%, respectively. Meanwhile, the spider-web hierarchical characteristics have less influence on the corresponding Peak Crushing Force ( PCF). Further, the mean crushing force is derived by dividing the profile into basic angle elements based on the Simplified Super Folding Element (SSFE) method. The theoretical calculation is in good agreement with the simulation results as the spider-web hierarchical honeycombs deform in Mode I. These results can provide valuable suggestions in the study and design of the new type hierarchical honeycombs.
Metabolic syndrome (MetS) represents a cluster of diseases that include diabetes and insulin resistance. A combination of these metabolic disorders damages liver function. We hypothesized here that HDAC1 inhibits FGF21 expression through histone deacetylation, thereby accentuating liver injury in rats with MetS. MetS rats induced by a high-fat diet were monitored weekly for blood pressure and body weight. The changes of hepatic injury parameters were also measured. The pathological changes in the liver were observed by HE staining and oil red O staining. We found that HDAC1 was increased in the liver of rats with MetS, while sh-HDAC1 reduced blood pressure, body weight and hepatic injury parameters. Improvement of structural pathological alterations and reduction of lipid deposition were observed after HDAC1 inhibition. Notably, HDAC1 inhibited FGF21 expression through histone deacetylation. The hepatoprotective effects of sh-HDAC1 on rats were reversed by adenovirus-mediated knockdown of FGF21. Moreover, METTL3 mediated the m6A modification of HDAC1 mRNA and increased its binding to IGF2BP2. Consistently, sh-METTL3 inhibited HDAC1 and increased FGF21 expression, thereby ameliorating liver injury in MetS rats. This study discovered that HDAC1 is capable of managing liver injury in MetS. Targeting HDAC1 may be an optimal treatment for MetS-related liver injury.
Objective
Pyogenic liver abscess (PLA) is a common surgical infectious disease caused by various pathogens. Klebsiella pneumoniae is a relatively recent cause, often affecting patients with low immunity. Endogenous endophthalmitis (EE), a rare and serious complication of PLA, may appear with eye symptoms before PLA. By reviewing a case of Klebsiella pneumoniae‐induced PLA complicated with EE, we want to summarize the information about the characteristics, causes, and complications of PLA based on the literature review.
Methods
This case report describes a 37‐year‐old male who had fever high to 39°C for 10 days experienced blurred vision followed by nonlight perception vision. He reported a history of diabetes irregularly taking oral medications and insulin therapy. Imaging examination found a large low‐density area in the right lobe of the liver with an unclear border and vague surrounding fat gap. The blood culture was not positive. The culture of the drainage fluid from the liver puncture showed Klebsiella pneumonia. Blood and liver puncture drainage fluid were sent for microbial high‐throughput gene detection with next‐generation sequencing technology (NGS), which confirmed the diagnosis of Klebsiella pneumoniae‐induced PLA complicated with EE.
Results
The patient's surgical incision had healed well at discharge, and he could feel light at his left eye. But the patient was lost to follow‐up since the third month after discharge.
Conclusion
By reviewing this case and summarize the information about the characteristics, causes, and complications of PLA based on the literature review, we concluded that it is necessary to promptly perform liver puncture drainage and empirically use antibiotics for patients with PLA, especially those with poor glycemic control, to avoid serious complications such as EE.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.