Tumor microenvironment turn-on nanoprobes that could specifically detect the occurrence of diseases possess great potential in early diagnosis. Here, a GSH activated nanoprobe was designed for fluorescence and 19 F magnetic resonance (MR) dualmodal turn-on imaging of tumors. Specifically, fluorescence AgInS 2 quantum dots (QDs for fluorescence imaging) were coencapsulated with perfluoro-15-crown-5-ether (P 19 FCE for 19 F MRI) by amphiphilic polymers and further coated with in situ formed manganese dioxide (MnO 2 ) nanoshells, which served as efficient fluorescence and 19 F MR quenchers due to energy transfer and paramagnetic relaxation effects, respectively. The overexpressed GSH in tumors would decompose the MnO 2 nanoshells, resulting in remarkable enhancement of both fluorescence and 19 F MRI signals of the nanoprobes, accordingly lighting up the tumor site.

It is challenging to fabricate multimodal imaging nanoprobes with high penetration depth and long blood circulation. Herein, we present multifunctional fluorinated nanoprobes (CFPP NPs) containing in situ formed copper chalcogenide nanoparticles for 19F magnetic resonance imaging (MRI) and photoacoustic imaging (PAI). The formed hydrophilic copper chalcogenide nanoassemblies demonstrated easy excretion stemming from facile disassembly, enhanced photothermal ability, and novel localized surface plasmon resonance (LSPR) absorption (centered at 1064 nm) in the “biological transparent” region. Both 19F MRI and PAI render these CFPP NPs suitable for multimodal imaging with high penetration depth and low background. Moreover, the chemo-photothermal synergistic therapy results suggest great potential in multimodal nanoprobes for imaging-guided tumor therapy applications.

Abstract. This paper reviews the definition and excellent properties of metal glass briefly. And it lists the preparation methods of metal glass. Furthermore, the urgent problems and the main research directions of metal glass are summarized, the development history of metal glass is reviewed, and the application direction of metal glass is sorted.