In Situ Fabrication of Nanoprobes for ¹⁹F Magnetic Resonance and Photoacoustic Imaging-Guided Tumor Therapy

Abstract

It is challenging to fabricate multimodal imaging nanoprobes with high penetration depth and long blood circulation. Herein, we present multifunctional fluorinated nanoprobes (CFPP NPs) containing in situ formed copper chalcogenide nanoparticles for 19F magnetic resonance imaging (MRI) and photoacoustic imaging (PAI). The formed hydrophilic copper chalcogenide nanoassemblies demonstrated easy excretion stemming from facile disassembly, enhanced photothermal ability, and novel localized surface plasmon resonance (LSPR) absorption (centered at 1064 nm) in the “biological transparent” region. Both 19F MRI and PAI render these CFPP NPs suitable for multimodal imaging with high penetration depth and low background. Moreover, the chemo-photothermal synergistic therapy results suggest great potential in multimodal nanoprobes for imaging-guided tumor therapy applications.

Recent Advances in Activatable Probes for Molecular Imaging by Stimuli‐Controlled Disassembly

“…Moreover, stimuli‐controlled disassembly could also potentiate multimodal imaging as it is capable of concurrently inducing switches in multiple imaging signals. [ 93–96 ] However, the difference in the imaging sensitivity of different modality has present substantial challenges. Considering that nanoprobes formed by co‐assembly could easily tune the concentration of different stimuli‐responsive small molecules, it may be applicable to work with stimuli‐controlled disassembly to overcome the limitations related to different sensitivity of different modality.…”

Design of a high-performance NIR-II nanoprobe by steric regulation for in vivo vasculature and tumor imaging

“…1,2 It offers real-time images with high sensitivity and high spatio-temporal resolution, which provides a new possibility for the conventional imaging methods, such as magnetic resonance imaging (MRI), ultrasound imaging (UI), positron emission tomography (PET) and computed tomography (CT). [3][4][5][6][7][8] However, short-wavelength ultraviolet-visible light is easily scattered or absorbed by biological tissues, leading to a poor tissue penetration. Near-infrared (NIR) light can overcome this drawback and has been widely used in fluorescence imaging in vivo.…”