We report a sulfonyl substituted phenylboronic acid containing monolith capillary that exhibited not only a strong boronate affinity at neutral pH but also secondary separation capability to cis-diol biomolecules.
A benzoboroxole-functionalized monolithic column was synthesized, which exhibited the best specificity and affinity towards cis-diol containing biomolecules as compared with the boronate affinity monolithic columns reported as well as significant secondary separation capability under acidic conditions.
A new Wulff-type boronate was designed and synthesized. Upon immobilization on a polymeric monolith and acidified as boronic acid, the ligand exhibited specific boronate affinity to cis-diol compounds at medium acidic pH condition.
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