Background: Coreopsis tinctoria is a traditional remedy for the management of various diseases including hepatitis. The hepatoprotective role of the plant is not scientifically explored till now. This study was designed to investigate the hepatoprotective potentials of the ethanol extract from C. tinctoria (CTEtOH) using an animal model of carbon tetrachloride (CCl 4 )-induced acute liver injury.
This study reports on a method for the speciation of iron in aqueous samples by the simultaneous analysis of divalent and trivalent iron ions with ion chromatography equipped with chemiluminescence detection (IC-CLD). Ferrous and ferric ions are first chelated by pyridine-2,6-dicarboxylic acid (PDCA) to form complexed anions, and separated by a mixed-bed ion-exchange column. The separated complexed ions are then detected with a CLD system containing luminol and hydrogen peroxide in a basic solution. This luminescence system has a linear dynamic range of ca. 3 orders of magnitude, with method detection limits as low as 7 μg L -1 for Fe(II) and 3 μg L -1 for Fe(III), measured in the simultaneous detection mode. This system resists interferences from common cations such as Cd, Ca, Cr, Cu, Mg, Ni, Pb, and Zn. Evaluation by analyzing real samples shows that this method is rapid, accurate, sensitive, and selective.
p-Hydroxyacetophenone (HAP) is a crucial chemical compound present in plants of the genus Artemisia, which are used in traditional therapies for treating jaundice, hepatitis, and inflammatory diseases. Nevertheless, the bioactivity of HAP remains to be identified in order to prove its importance in the plants of genus Artemisia. This study investigated the antioxidative, antinociceptive, and anti-inflammatory effects of HAP, and probed its possible molecular mechanisms. Our results revealed that HAP (80 mg/kg, intraperitoneally) in vivo reduced the acetic acid-induced writhing response and formalin-induced licking time. Moreover, in the λ-carrageenan-induced acute-inflammatory paw edema model in mice, HAP significantly improved hind paw swelling and neutrophil infiltration. In a homogenized paw tissue examination, HAP attenuated pro-inflammatory cytokines, such as tumor necrosis factor-α, interleukin-1β, and interleukin-6. Simultaneously, HAP also inhibited the production of nuclear factor kappa B, cyclooxygenase-2, and nitric oxide (NO). Another examination revealed that HAP exerted anti-inflammatory activity by decreasing malondialdehyde levels in the edematous paw through increasing the activities of superoxide dismutase, glutathione peroxidase, and glutathione reductase in the liver. These findings may be beneficial in understanding the therapeutic effects of some plants of the genus Artemisia in the pretreatment of inflammation-associated diseases.
Inexpensive household steel wool was used as a reducing agent for the reductive dechlorination of polychlorinated biphenyls (PCBs) in supercritical carbon dioxide (scCO 2 ). Untreated steel wool does not produce significant results. Steel wool treated with 6 N HCl, however, showed complete reduction of the PCBs (Aroclor 1254) used. Scanning electron microscopy (SEM) reveals the formation of nanoscale pits (nanopits) on the surface of steel wool after etching with HCl. These nanopits are responsible for the high efficiency of the hydrodechlorination process.
Background:Liver is one of the body's important vital metabolic organ. World health organization(WHO) has reported that millions people were killed by liver disease, ever year. This study investigated that if coptisine has protective-effect on the CCl4-induced acute liver damage in mice. Methods: Coptisine, an isoquinoline alkaloid from Coptis chinensis, was administered at the doses of 10, 20 and 40 mg/kg (p.o.) to mice for 6 days. At the 6th day, intraperitoneally inject CCl4 (0.2%, v/v in olive oil, 10ml/kg) after coptisine administration for 1 h. The mice were sacrificed after 24 hours. Results: The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in CCl4-intoxicated mice was raised and markedly suppressed by coptisine. The expression of Interleukin 6(IL-6), phosphorylated phosphatidylinositide 3-kinase (PI3K), phosphorylated protein kinase B (Akt), and nuclear factor kappa-light-chainenhancer of activated B cells(NF-kB) were increase in CCl4-intoxicated mice and significantly decrease by coptisine. Histopathological changes were reduced and the expression was markedly attenuated by coptisine 20 mg/kg. Conclusions: The results of this study indicate that coptisine could be effective in protecting the liver from acute CCl4induced injury. The hepatoprotective mechanisms of coptisine may through regulate the IL-6 pathway.
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