Stretching is a major treatment for restoring the ankle range of motion while decreasing the ankle stiffness. An automatic stretching machine can provide long-term continual stretching at home. However, no commercial stretching machines are currently available, and therefore, no safety guidelines exist for them. In this study, we prototyped a stretching machine using a chassis from a commercial foot exerciser for preventing disuse syndrome, and then proposed three safety concepts as general requirements for stretching machines. The concepts were determined based on risk assessments, which included (1) preventing excessive force from being applied to the foot, (2) responding to the ankle stiffness and the range of motion of each different individual, and (3) preventing unintended operations by the user. The above concepts allowed us to develop a stretching machine taking into account safety measures. Further, the stretching effect of the prototype was tested on sixteen healthy young subjects ( 22.3 ± 3.6 years ). We found that the passive resistance of the subjects at specific dorsiflexion angles decreased significantly after stretching the ankle using the prototyped machine.
An atom moving in a spatially periodic field experiences a temporary periodic perturbation and undergoes a resonance transition between atomic internal states when the transition frequency is equal to the atomic velocity divided by the field period. We demonstrated that spin nutation was induced by this resonant transition in a polarized rubidium (Rb) atomic beam passing through a magnetic lattice. The lattice was produced by current flowing through an array of parallel wires crossing the beam. This array structure, reminiscent of a multiwire chamber for particle detection, allowed the Rb beam to pass through the lattice at a variety of incident angles. The dephasing of spin nutation was reduced by varying the incident angle.
Gangliosides, a family of glycosphingolipids that contain sialic acid, are abundant on the neuronal cell membranes, but their precise functions in the central nervous system remain largely undefined. In a previous study of GalNAc-T(-/-) mice engineered to lack beta1,4-N-acetylgalactos-aminyltransferase (GM2/GD2 synthase) to abolish any, complex gangliosides, we observed the reduction of nerve conduction velocity but did not find any obvious morphological change in the brain. In the present study, we observed morphological changes in the nerve fiber tracts of the spinal cord in these mice. In GalNAc-T(-/-) mice, the number of degenerated axons was markedly increased in the dorsal funiculus, tract of Lissauer, and dorsolateral funiculus of the cervical segment of the spinal cord as well as the dorsal funiculus and tract of Lissauer of the lumbar segment of the spinal cord. There were also increased numbers of unmyelinated fibers in GalNAc-T(-/-) mice. Loosened myelin sheaths and myelin sheaths separated from axons by wide spaces were also observed in GalNAc-T(-/-) mice. These results provide a morphological basis for the previously observed reduction in the nerve conduction velocity and suggest that complex gangliosides are essential for the maintenance of myelin and the integrity of nerve fibers of the spinal cord.
The articular capsules between the thoracic vertebrae, which have physiologically different functions from those of other levels of the vertebrae, have yet to be subjected to neuro-anatomical and fine structural analysis. In the present study, we analyzed serial frozen sections of decalcified thoracic vertebrae in human fetuses, and identified the articular capsule tissue with its unique distribution of elastic fibers. The fine structure of the elastic fibers was studied by transmission electron microscopy. In the early-stage fetus, the fibrous membrane forming the lateral intervertebral articular capsule contained abundant thin elastic fibers consisting of microfibrils. In the late-stage fetus, the lateral capsule of fibrous membrane was occupied by thick elastic fibers. A medial articular capsule, namely the ligamenta flava, contained numerous thick elastic fibers in both early and late-stage fetuses. The distributional differences in nerve fibers between early and late-stage fetuses were determined by immunostaining, using antibodies raised against protein gene product 9.5 (PGP 9.5; ubiquitin carboxyl-terminal hydrolase). Innervation by PGP 9.5 immunoreactive fibers was limited to the areas of the articular capsules near the blood vessels, which may indicate their functional relation with blood flow. No PGP 9.5 immunoreactive fibers were found in the ligamenta flava of the late-stage fetus. Innervation might be directly involved in the development of the intervertebral articular capsules in normal human fetuses.
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