Summary
Acute mesenteric ischaemia is a syndrome caused by inadequate blood flow through the mesenteric vessels, resulting in ischaemia and eventual gangrene of the bowel wall. Although relatively rare, it is a potentially life‐threatening condition. The maintenance of haemodynamic stability, along with adequate oxygen saturation, and the correction of any electrolyte imbalance, are of the utmost importance. However, nicotinamide adenine dinucleotide (NAD) biosynthesis modulation by precursor introduction can also be a powerful tool for preventing injury. Nicotinamide riboside is a pyridine‐nucleoside form of vitamin B3 that functions as a precursor to NAD+. The present study investigated nicotinamide riboside's effect on endothelium functional state, microcirculation and intestinal morphology in acute mesenteric ischaemia and reperfusion. Mesenteric ischaemia was simulated after the adaptation period (15 minutes) by occluding the superior mesenteric artery for 60 minutes, followed by a reperfusion period of 30 minutes. The functional state of intestinal microcirculation was evaluated by laser Doppler flowmetry. Endothelial functional activity was studied by using wire myography. Intestinal samples were stained with haematoxylin and eosin for histological analysis. The results revealed that nicotinamide riboside protects the intestinal wall from ischaemia‐reperfusion injury, as well as improving the relaxation function of mesenteric vessels. Nicotinamide riboside's protective effect in small intestine ischaemia‐reperfusion can be used to reduce ischaemia‐reperfusion injury, as well as to preserve intestinal grafts until transplant.
The possibility of designing recommendation system for library e-catalog as a recommendation service is examined. Several options for recommendations were considered, i.e. collaborative filtering method and content-based recommendations. The findings were used for building the recommendation service based on two recommendation algorithms – document-based collaborative filtering and content-based recommendations. Anonymized data on fulfilled orders and library’s e-catalog data are used as input data for recommendation system.
The authors introduce an approach to design library discovery service based on the standard solution stack. They examine the approach technological aspects, e.g. object data model, search model and software architecture. The software under development as related to ZooPARK project is characterized in brief.
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