ABSTRACT:To provide theoretical insight into the structures and properties of Sc 3 N@C 80 , which has been isolated in high yield and purity as a new stable endohedral metallofullerene, density functional calculations are carried out for the Sc 3−n La n N@C 80 (n = 0-3) series. Because of electron transfer from Sc 3 N to C 80 , the electronic structure of Sc 3 N@C 80 is formally described as (Sc 3 N) 6+ C 6− 80 . The encapsulated Sc 3 N cluster takes a planar structure with long Sc-Sc distances and is highly stabilized inside the I h cage of C 80 , which rotates rapidly. As the number of La atoms increases, the Sc 3−n La n N cluster is forced to maintain a pyramidal structure in Sc 3−n La n N@C 80 . In addition, the C 80 cage takes an open-shell electronic structure due to an increase in the number of electrons transferring from Sc 3−n La n N. These make the endohedral structure less stable and more reactive.
These results show that declines in finger dexterity can reflect declining cognitive function, and that measurement of finger dexterity using our smart terminal device can facilitate screening of large groups for MCI or AD. Geriatr Gerontol Int 2018; 18: 907-914.
Background
Evidence of factors associated with psoriasis from large population-based cohort studies is scarce.
Objective
We aimed to explore the risk factors of late-onset psoriasis.
Methods
This study included 487,835 Japanese participants aged 40-107 years, who were followed prospectively from 2012 to 2018 using individually linked databases between annual health checkups and medical claims.
Results
During the study period, 2793 patients (0.57%) newly developed psoriasis; 13.8% had moderate-to-severe psoriasis. In the multivariate analysis, factors associated with psoriasis onset were age (hazard ratio [HR] 1.11 {95% confidence interval [CI]: 1.06-1.16}), male sex (HR: 1.11 [95% CI: 1.02-1.21]), body mass index (HR: 1.09 [95% CI: 1.05-1.14]), smoking (HR: 1.46 [95% CI: 1.31-1.63]), not exercising ≥1 hour per week (HR: 1.13 [95% CI: 1.05-1.22]), and gamma-glutamyl transpeptidase (HR: 1.04 [95% CI: 1.01-1.06]). When we used weight increment of ≥10 kg since the age of 20 years instead of body mass index in the multivariate model, this was also a risk factor (HR: 1.12 [95% CI: 1.04-1.21]).
Limitations
This study targeted people aged >40 years, thereby narrowing the search to the risk factors of late-onset psoriasis.
Conclusion
We showed that increasing age, male sex, body mass index, smoking, low physical activity, weight gain, and gamma-glutamyl transpeptidase are associated with late-onset development of psoriasis and revealed a relationship between liver dysfunction and psoriasis development.
Objective: Decreased finger dexterity can impede a person's daily activities. The present study examined finger dexterity in individuals with mild cognitive impairment (MCI) and patients with Alzheimer's disease (AD) compared with healthy older adults using a magnetic sensing finger tapping device (UB-1). Methods: Finger-to-thumb tapping tasks were carried out by 23 patients who were diagnosed with AD or MCI at the authors' hospital (AD/MCI group) and 22 members of their families (healthy control group), and measurement parameters were calculated. Mini-Mental State Examination (MMSE) was carried out to assess cognitive function and the association between finger function and the results of MMSE was evaluated. Additionally, the measurement parameters were compared between the AD/MCI group (n = 14) and the healthy control group (n = 13) after adjusting for age. Results: A correlation between finger function and MMSE results was observed in five measurement parameters (r ≥ 0.6). Additionally, in the AD/MCI group, the total traveling distance was shorter compared to that in the healthy control group and rhythm perturbations were observed (p < 0.05).Discussion: In the present study, the AD/MCI group showed decreased finger dexterity, which was also found to be associated with decline in cognitive function. It is suggested that assessment of finger dexterity can be used as an indicator of cognitive function.
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