The clinical complications occurring after 111 dogs had undergone arterial punctures were reviewed in relation to the dogs' breed, bodyweight, age, sex and underlying diseases. Seven of the dogs had moderate to extensive ecchymoses, which were significantly more common in dogs under 3.5 kg in bodyweight and in dogs with disorders of the cardiovascular system.
ABSTRACT. Open heart surgery was performed on two groups of dogs under extracorporeal circulation with or without hypothermia to investigate hemodynamic changes during extracorporeal circulation. During hypothermic cardiopulmonary bypass (CPB), arterial O 2 tension and postoperative blood pressure were favorably maintained, indicating that hypothermic extracorporeal circulation can be performed for a long period of time. On the other hand, during normothermic CPB, the average surgical duration was significantly shorter, and marked shifts in the concentrations of various enzymes were suppressed. However, due to reductions in arterial O 2 tension, the length of cardiac arrest time was restricted, demonstrating that this method is suitable for performing extracorporeal circulation for CPB of relatively short duration. If circulation circuitry can be improved, such as through the development of a surpassing oxygenator, normothermic CPB would incur less stress on the body, thus making it preferential to hypothermic CPB in most cases.-KEY WORDS: canine, extracorporeal circulation, hypothermia, normothermia.J. Vet. Med. Sci. 61(4): 331-336, 1999 normothermic CPB in humans have yet to be fully clarified. The present study investigate the effect of extracorporeal circulation using an artificial heart-lung machine with or without hypothermia on pathophysiology of dogs (in particular, hemodynamics). MATERIALS AND METHODS Animals:Fourteen clinically healthy male beagles were examined. All dogs were cared for in accordance with the experimental animal guidelines of Tokyo University of Agriculture and Technology. The animals were randomly divided into two groups. Group H (hypothermic CPB, age 2.2 ± 1.2 years (mean ± standard error), weight 10.0 ± 0.8 kg, n=7), in which their body temperature was reduced to 24-26°C, and Group N (normothermic CPB, age 2.0 ± 0.4 years, weight 10.4 ± 0.3kg, n=7), in which their body temperature was maintained at 36°C. To obtain clinically useful data, open heart surgery was performed assuming that the dogs would live for at least one month after surgery.Surgical technique and cardiopulmonary bypass system: Dilation and remodeling of the right ventricular outflow tract of all dogs was performed using a patch graft technique as if they had pulmonary stenosis. The artificial heart-lung machine (NAPS-III, Fig. 1) [18,19,21] that was used in the present study consists of three two-roller pumps, a membrane oxygenator, a heat exchanger, and a circuit. Before starting extracorporeal circulation, the machine was primed with lactated Ringer solution, 5% glucose, 7% sodium bicarbonate, and 20% mannitol, without using whole blood. The dogs were pretreated with atropine sulfate (0.04 mg/kg) and acepromazine maleate (0.4 mg/kg), and whenCurrent techniques in open heart surgery in humans involve establishing extracorporeal circulation using an artificial heart-lung machine. In this method, the artificial heart-lung machine performs systemic respiration and circulation so that the heart can be temporarily sto...
The accuracy of a portable blood gas analyzer (OPTI 1) was evaluated using canine blood and aqueous control solutions. Sixty-four arterial blood samples were collected from 11 anesthetized dogs and were analyzed for pH, partial pressure of carbon dioxide (PCO2) partial pressure of oxygen (PO2), and bicarbonate concentration ([HCO3-]) values by the OPTI 1 and a conventional blood gas analyzer (GASTAT 3). The conventional analyzer was considered as a standard against which the OPTI 1 was evaluated. Comparison of OPTI 1 results with those of GASTAT 3 by linear regression analysis revealed a high degree of correlation with the GASTAT 3 (r = .90-.91). The mean +/- SD of the differences between OPTI 1 and GASTAT 3 values was -0.008 +/- 0.017 for pH, -0.88 +/- 3.33 mm Hg for PCO2, 3.71 +/- 6.98 mm Hg for PO2, and -0.34 +/- 1.45 mEq/L for [HCO3-]. No statistically significant difference was found between the OPTI 1 and the GASTAT 3. Agreement between these 2 methods is within clinically acceptable ranges for pH, PCO2, PO2, and [HCO3-]. The coefficients of variation for measured pH, PCO2, and PO2 values of 3 aqueous control solutions (acidic, normal, and alkalotic) analyzed by the OPTI 1 ranged from 0.047 to 0.072% for pH, 0.78 to 1.81% for PCO2, and 0.73 to 2.77% for PO2. The OPTI 1 is concluded to provide canine blood gas analysis with an accuracy that is comparable with that of conventional benchtop blood gas analyzers.
The accuracy of a portable blood gas analyzer (OPTI 1) was evaluated using canine blood and aqueous control solutions. Sixty-four arterial blood samples were collected from 11 anesthetized dogs and were analyzed for pH, partial pressure of carbon dioxide (PCO2) partial pressure of oxygen (PO2), and bicarbonate concentration ([HCO3-]) values by the OPTI 1 and a conventional blood gas analyzer (GASTAT 3). The conventional analyzer was considered as a standard against which the OPTI 1 was evaluated. Comparison of OPTI 1 results with those of GASTAT 3 by linear regression analysis revealed a high degree of correlation with the GASTAT 3 (r = .90-.91). The mean +/- SD of the differences between OPTI 1 and GASTAT 3 values was -0.008 +/- 0.017 for pH, -0.88 +/- 3.33 mm Hg for PCO2, 3.71 +/- 6.98 mm Hg for PO2, and -0.34 +/- 1.45 mEq/L for [HCO3-]. No statistically significant difference was found between the OPTI 1 and the GASTAT 3. Agreement between these 2 methods is within clinically acceptable ranges for pH, PCO2, PO2, and [HCO3-]. The coefficients of variation for measured pH, PCO2, and PO2 values of 3 aqueous control solutions (acidic, normal, and alkalotic) analyzed by the OPTI 1 ranged from 0.047 to 0.072% for pH, 0.78 to 1.81% for PCO2, and 0.73 to 2.77% for PO2. The OPTI 1 is concluded to provide canine blood gas analysis with an accuracy that is comparable with that of conventional benchtop blood gas analyzers.
Background “Arterialization” of the dorsal hand vein is well‐established in human medicine, but not in veterinary medicine. Objectives To compare cephalic and saphenous venous blood collected by continuously heating the paws to 37°C (“arterialization”), with arterial blood (AB) for measurement of blood gas variables in well‐perfused dogs. Animals Eight healthy dogs. Methods Experimental study. Fore and hind paws were continuously heated to 37°C to “arterialize” cephalic and saphenous venous blood. AB and “arterialized” cephalic and saphenous venous blood (ACV and ASV, respectively) were simultaneously collected from lightly anesthetized dogs with induced metabolic and respiratory acid‐base disorders. The pH, partial pressures of carbon dioxide (PCO2) and oxygen (PO2), bicarbonate concentration [HCO3−], and base excess (BE) were measured once in each state. Systolic blood pressure was maintained above 100 mm Hg. The AB, ACV, and ASV values were compared. Results The pH, [HCO3−], and BE values had no significant difference and good agreement, the PCO2 values had a strong correlation (correlation coefficient of .91‐1.00), and the PO2 values had a significant difference (P < .01) and poor agreement between AB and ACV, and between AB and ASV. The PCO2 values of ASV overestimated those of AB by ~3.0 mm Hg, which was considered within clinically allowable limits, while those of ACV were not within clinically allowable limits. Conclusions and Clinical Importance Under experimental conditions, the ASV samples were more identical to the AB samples than the ACV samples for pH, PCO2, [HCO3−], and BE values in well‐perfused dogs. The saphenous vein is suitable for “arterialization.”
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