Flexible pressure sensors have attracted more and more attention recently due to their broad applications, such as electronic skin and wearable electronics for health monitoring. Among them, capacitive flexible pressure...
A hydrosoluble light-sensitive polymer
named PSAG (poly-styrenesulfonate
acrylic acid glycidyl methacrylate) was synthesized by acrylic acid (AA), sodium
4-styrenesulfonate (SS), and glycidyl methacrylate (GMA). PSAG is
used to modify multiwall carbon nanotubes (MWCNTs) with a length diameter
between 0.004 and 0.016. An inkjet conductive ink was formed by well-dispersed
MWCNTs in aqueous and organic solvents, which could adjust the surface
tension and viscosity of the ink. Gas sensors were then fabricated
using this conductive ink on a household inkjet printer. The sensors
demonstrated good reproducibility and acceptable recovery time (<200
s) to ammonia, methanol, and acetone. The resistance of the inkjet-printed
sensor electrodes remained stable in the process of bending the sensors
to different angles because of ultraviolet curing.
Gene therapy, which aims to cure diseases by knocking out, editing, correcting or compensating abnormal genes, provides new strategies for the treatment of tumors, genetic diseases and other diseases that are closely related to human gene abnormalities. In order to deliver genes efficiently to abnormal sites in vivo to achieve therapeutic effects, a variety of gene vectors have been designed. Among them, peptide-based vectors show superior advantages because of their ease of design, perfect biocompatibility and safety. Rationally designed peptides can carry nucleic acids into cells to perform therapeutic effects by overcoming a series of biological barriers including cellular uptake, endosomal escape, nuclear entrance and so on. Moreover, peptides can also be incorporated into other delivery systems as functional segments. In this review, we referred to the biological barriers for gene delivery in vivo and discussed several kinds of peptide-based nonviral gene vectors developed for overcoming these barriers. These vectors can deliver different types of genetic materials into targeted cells/tissues individually or in combination by having specific structure–function relationships. Based on the general review of peptide-based gene delivery systems, the current challenges and future perspectives in development of peptidic nonviral vectors for clinical applications were also put forward, with the aim of providing guidance towards the rational design and development of such systems.
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