A novel fiber optic localized plasmon resonance (FO-LPR) sensor composed of a D-shape optical fiber was proposed and demonstrated in the present study. The D-shape optical fiber was fabricated by a femtosecond laser micromachining system. The dimensions of the D-shape zone were 100 μm in depth measured from the surface of the polymer jacket layer, and the total length was 6 mm. After annealing treatment, the mean roughness of the surface was 231.7 nm as determined by AFM. The exposed surface of the D-shape fiber was modified with self-assembled gold nanoparticles to produce the FO-LPR sensor. The response of the sensor shows that the signal increases linearly with increasing refractive index. The sensor resolution of the sensor was determined to be 4.1×10 -4 RIU.
A novel micro immunoassay chip for detecting biomarkers in blood plasma has been developed by using an injector-based antibody immobilization. Since multiple detectors were made in a single channel, the chip was able to detect various biomarkers simultaneously. UV Laser processing of the substrate was performed to enhance immobilization of the antibody. In P1CP, which is a biomarker for osteoporosis, this simple plastic chip requires only 1 micro liter per lane of blood plasma and 30 min of reaction time, one twentieth the sample volume required for the ELISA-kit and six times the through put.
The Femtoprint project, a European project, aims at demonstrating the use of low-energy laser pulses (i.e. below the ablation threshold) to manufacture monolithically integrated devices including optofluidic, optomechanical and photonic devices. The longer-term objective is the implementation of a versatile table-top machining center. This paper summarizes the project progress to date and demonstrates the potential of this approach through various illustrative examples.
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