We have recently seen two cases of hyperpigmentation in children, which was reticulate and distributed in a zosteriform fashion. As another two cases of hyperpigmentation of this kind in children have been reported previously, described as reticulate hyperpigmentation distributed in a zosteriform fashion, this gives a total of four cases of hyperpigmentation of this kind reported recently from Japan. These four cases differed from progressive cribriform and zosteriform hyperpigmentation, the condition which these cases resembled most closely, with respect to the age of onset of the hyperpigmentation, which in the four Japanese cases was not confined to a dermatome. Like a variant of incontinentia pigmenti (IP), all four cases showed eosinophilia. But they differed from IP in that there was no inflammatory stage, no pigmentary incontinence detectable on histology, and no evidence that the condition was hereditary. These four cases do not conform completely to any described entities and we suggest that they represent a new clinical entity.
. AbstructThe differential diagnostic capacity of a multi-directional sensing catheter with intraluminal objects was evaluated by fluorescence analysis following administration of a photosensitizer. The measurement catheter is 1.7 mm in diameter and is constructed with cross-sectional arrangement of 6 sensor bundle units and a centered guide wire lumen. Fluorescence was analyzed by polychrometer and amplified CCD camera with an image intensifier. The excitation light was 405nm wavelength obtained from an Xe-Hg lamp using a band pass filter. In vivo and in vitro fluorescence analysis of normal and atherosclerotic rabbit aorta was performed following intravenous administration of 5 mg/kg Hematoporphyrin Derivatives (HpD) 24 hours before. The diagnostic algorithm was based on the spectrum profile, a peak at 405nm and Plaque Index (PI=[F1630-(O.76F1600-i-O.24F1725)] /F1600) was identified for the fluorescence spectrum detected by each one of sensing units. Blood and fresh thrombus showed a flat profile without a 405nm peak (sens.=83.3%, spec.=100%). The normal arterial wall was PI O.15 with a 405nm peak. Intima of less than 200p.m was O.15
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