We present MMDetection, an object detection toolbox that contains a rich set of object detection and instance segmentation methods as well as related components and modules. The toolbox started from a codebase of MMDet team who won the detection track of COCO Challenge 2018. It gradually evolves into a unified platform that covers many popular detection methods and contemporary modules. It not only includes training and inference codes, but also provides weights for more than 200 network models. We believe this toolbox is by far the most complete detection toolbox. In this paper, we introduce the various features of this toolbox. In addition, we also conduct a benchmarking study on different methods, components, and their hyper-parameters. We wish that the toolbox and benchmark could serve the growing research community by providing a flexible toolkit to reimplement existing methods and develop their own new detectors. Code and models are available at https: //github.com/open-mmlab/mmdetection. The project is under active development and we will keep this document updated.

The kidney not only regulates fluid and electrolyte balance but also functions as an endocrine organ. For instance, it is the major source of circulating erythropoietin and renin. Despite currently available therapies, there is a marked increase in cardiovascular morbidity and mortality among patients suffering from end-stage renal disease. We hypothesized that the current understanding of the endocrine function of the kidney was incomplete and that the organ might secrete additional proteins with important biological roles. Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine). In humans, renalase gene expression is highest in the kidney but is also detectable in the heart, skeletal muscle, and the small intestine. The plasma concentration of renalase is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. Renalase infusion in rats caused a decrease in cardiac contractility, heart rate, and blood pressure and prevented a compensatory increase in peripheral vascular tone. These results identify renalase as what we believe to be a novel amine oxidase that is secreted by the kidney, circulates in blood, and modulates cardiac function and systemic blood pressure.

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Based upon the 1970 aero-photo topographic map, and TM/ETM satellite images taken in 1991 and 2000, the authors artificially interpreted boundaries of lake and glaciers in Nam Co Catchment, and quantified lake-glacier area variations in different stages by "integrated method" with the support of GIS. Results show that from 1970 to 2000, lake area increased from 1942.34 km 2 to 1979.79 km 2 at a rate of 1.27 km 2 /a, while glacier area decreased from 167.62 km 2 to 141.88 km 2 at a rate of 0.86 km 2 /a. The increasing rate of lake in 1991-2000 was 1.76 km 2 /a that was faster than 1.03 km 2 /a in 1970-1991, while in the same period of time, the shrinking rates of glaciers were 0.97 km 2 /a and 0.80 km 2 /a respectively. Important factors, relevant to lake and glacier response to the climate, such as air temperature, precipitation, potential evapotranspiration and their values in warm and cold seasons, were discussed. The result suggests that temperature increasing is the main reason for the accelerated melting of glaciers. Lake expansion is mainly induced by the increase of the glacier melting water, increase of precipitation and obvious decrease of potential evapotranspiration. Precipitation, evaporation and their linkages with lake enlargement on regional scale need to be thoroughly studied under the background of global warming and glacier retreating.

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