The Songhua River plays a key role in the national development of China, owing to its unique natural condition and resources. Recent changes in the streamflow in the Songhua River are important with regard to local sustainable development and management under the background of global warming and aggravating soil erosion. In order to detect changes in the streamflow, 2) The streamflow series followed the pattern of a wet-dry-wet-dry cycle pattern over the past 50 years. In the mainstream of Songhua River, wet years mainly occurred during the periods of 1955-1966 and 1984-1993, while dry years mainly occurred in the 1970s and after 2000. (3) Within the 50-year scale, the streamflow series appeared in the main periods of circa 33-, 13-and 4-year, in which the 33-year periodicity is the strongest. (4) Precipitation and temperature directly influenced the streamflow in the mainstream of the basin. The discharge was positively correlated with the precipitation and negatively correlated with the temperature. In addition, human activity was another important driving factor for streamflow change. (5) In the mainstream of Songhua River basin, the influences on streamflow can be divided into three periods: 1955-1976, 1977-1997, and 1998-2004. In the first period climate change played a dominant role, and during the latter two periods human influences were enhanced significantly.