Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic transformation. The rapid activation of immune cells plays a critical role in BBB disruption after ischemic stroke. Infiltrating blood-borne immune cells (neutrophils, monocytes, and T lymphocytes) increase BBB permeability, as they cause microvascular disorder and secrete inflammation-associated molecules. In contrast, they promote BBB repair and angiogenesis in the latter phase of ischemic stroke. The profound immunological effects of cerebral immune cells (microglia, astrocytes, and pericytes) on BBB disruption have been underestimated in ischemic stroke. Post-stroke microglia and astrocytes can adopt both an M1/A1 or M2/A2 phenotype, which influence BBB integrity differently. However, whether pericytes acquire microglia phenotype and exert immunological effects on the BBB remains controversial. Thus, better understanding the inflammatory mechanism underlying BBB disruption can lead to the identification of more promising biological targets to develop treatments that minimize the onset of life-threatening complications and to improve existing treatments in patients. However, early attempts to inhibit the infiltration of circulating immune cells into the brain by blocking adhesion molecules, that were successful in experimental stroke failed in clinical trials. Therefore, new immunoregulatory therapeutic strategies for acute ischemic stroke are desperately warranted. Herein, we highlight the role of circulating and cerebral immune cells in BBB disruption and the crosstalk between them following acute ischemic stroke. Using a robust theoretical background, we discuss potential and effective immunotherapeutic targets to regulate BBB permeability after acute ischemic stroke.
Renewable polymers have attracted considerable attentions in the last two decades, predominantly due to their environmentally friendly properties, renewability, good biocompatibility, biodegradability, bioactivity, and modifiability. The nanofibers prepared from the renewable polymers can combine the excellent properties of the renewable polymer and nanofiber, such as high specific surface area, high porosity, excellent performances in cell adhesion, migration, proliferation, differentiation, and the analogous physical properties of extracellular matrix. They have been widely used in the fields of wound dressing to promote the wound healing, hemostasis, skin regeneration, and treatment of diabetic ulcers. In the present review, the different methods to prepare the nanofibers from the renewable polymers were introduced. Then the recent progress on preparation and properties of the nanofibers from different renewable polymers or their composites were reviewed; the application of them in the fields of wound dressing was emphasized.
Using gangue backfilling in underground coal mining not only controls the roof deformation in the gob area but also reduces the amount of mining waste rock. However, due to the limitations of the complicated engineering conditions, backfilling mining in the steep coal seam is not widely applied. In this study, a long-distance backfilling technology with a scraper winch for a steep coal seam was proposed and applied in a flexible shield supporting working face in Datai Mine, Beijing. Aiming at the problem of the decreasing backfilling ratio in field practice, numerical simulation was carried out to research the moving law of gangue in the goaf. The gangue mainly experienced four stages: gangue landslide stage, small-scale subsidence stage, funnel-shaped subsidence stage, and large-scale subsidence stage. The moving area of the gangue could be divided into five areas including a motionless area, a landslide area, a subsidence area, a funnel-shaped subsidence area, and a to-be-backfilled area. With the increase of the inclined length of the working face, the moving time of the gangue increased gradually. Based on the simulation results, the scheme of backfilling and mining in Datai Mine was optimized, for which the inclined length of the working face was shortened, and a higher backfilling ratio was obtained.
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