Lymphatic absorption of PlsCho is much higher than that of PlsEtn in rats, and plasmalogens are re-esterified as 20:4-rich forms in the small intestine.

No abstract

The adsorption behavior of energy-related gases onto ZIF-8 was investigated using terahertz waves. Comparison of the terahertz transmission spectra of ZIF-8 before and after exposure to the gases revealed that the 2 THz vibrational mode was involved in the gate-opening motion of organic linker molecules. The adsorption properties of each gas were detailed by monitoring the intensities of the 2 THz absorption peak.

A new route to the diarylheptanoid diospongins A and B was developed. The key step is a novel, one‐pot, sequential dirhodium(II) tetrakis[(S)‐3‐(benzo‐fused phthalimido)‐2‐piperidinonate] [Rh2(S‐BPTPI)4] catalyzed enantioselective hetero‐Diels–Alder/TMSOTf‐catalyzed Mukaiyama–Michael reaction process. The sign of the optical rotation of natural diospongin B was determined to be (+) and not (–) as was originally reported.

Azithromycin has been reported to increase the risk of death from cardiovascular causes among patients with high baseline risk. Since the information is still limited to bridge the gap between electrophysiological properties of azithromycin in vitro and cardiac death in patients, we initially assessed its electropharmacological effects in doses of 3 and 30 mg/kg, i.v., with the halothane-anesthetized dogs (n = 4). The low dose provided 5.2 times higher than the therapeutic concentration, whereas the high dose attained 17.0 times higher. The high dose delayed the ventricular repolarization in a reverse use-dependent manner, reflecting blockade of the rapid component of delayed rectifier K(+) current, and the potency was relatively weak; namely, maximum change in QTc was +20 ms (+5.6%). The high dose also induced the negative inotropic effect possibly through Ca(2+) channel-independent pathway. In order to clarify proarrhythmic risk, 30 mg/kg, i.v., of azithromycin was examined with the chronic atrioventricular block dogs (n = 4). Azithromycin neither induced torsade de pointes nor affected beat-to-beat variability of repolarization. Thus, azithromycin can be considered to lack proarrhythmic potential, but caution has to be paid on its use for patients with left ventricular dysfunction.