Although antibiotics have been widely used in clinical applications to treat pathogenic infections at present, the problem of drug-resistance associated with abuse of antibiotics is becoming a potential threat to human beings. We report a biohybrid nanomaterial consisting of antibiotics, enzyme, polymers, hyaluronic acid (HA), and mesoporous silica nanoparticles (MSNs), which exhibits efficient in vitro and in vivo antibacterial activity with good biocompatibility and negligible hemolytic side effect. Herein, biocompatible layer-by-layer (LBL) coated MSNs are designed and crafted to release encapsulated antibiotics, e.g., amoxicillin (AMO), upon triggering with hyaluronidase, produced by various pathogenic Staphylococcus aureus (S. aureus). The LBL coating process comprises lysozyme (Lys), HA, and 1,2-ethanediamine (EDA)-modified polyglycerol methacrylate (PGMA). The Lys and cationic polymers provided multivalent interactions between MSN-Lys-HA-PGMA and bacterial membrane and accordingly immobilized the nanoparticles to facilitate the synergistic effect of these antibacterial agents. Loading process was characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and X-ray diffraction spectroscopy (XRD). The minimal inhibition concentration (MIC) of MSN-Lys-HA-PGMA treated to antibiotic resistant bacteria is much lower than that of isodose Lys and AMO. Especially, MSN-Lys-HA-PGMA exhibited good inhibition for pathogens in bacteria-infected wounds in vivo. Therefore, this type of new biohybrid nanomaterials showed great potential as novel antibacterial agents.

As eries of rigid nonconjugated polyimide (PI)based thermally activated delayed fluorescence (TADF) polymers were reported for the first time,b ased on a" TADF-Linker-Host" strategy.A mong of which,t he TADF unit contains at ypical TADF luminous core structure,t he "Host" unit exhibits effective conjugation length that endows polyimide with high triplet energy,a nd the "Linker" unit has an aliphatic ring structure to improve solubility and inhibits intramolecular charge transfer effect. All the TADF polymers exhibit high thermal stability (T g > 308.7 8 8C) and refractive index (1.76-1.79). Remarkably,highly-efficient polymer lightemitting diodes (PLEDs) based on the polymers are successfully realized, leading to am aximal external quantum efficiency of 21.0 %a long with lowe fficiency roll-off.S uch outstanding efficiency is amongst the state-of-the-art performance of nonconjugated PLEDs,confirming the effectiveness of structural design strategy,p roviding helpful and valuable guidance on the development of highly-efficient fluorescent polymer materials and PLEDs.

Responsive cross-linked micelles (x-micelles) based on polyurethane with photo-responsive coumarin derivatives and pH-responsive hydrazone groups were synthesized.

A facile organogel was developed to improve drug release and transdermal delivery, and to increase bactericidal activity over 80% in vivo.

Luminophores usually suffer from luminescent quenching when introduced into a polymer backbone or side chain, which leads to the inefficient luminescence or even no luminescence of the polymer. In this work, alicyclic imide rings were found to be capable of balancing the donor–acceptor properties between the rigid spacer and the aggregation-induced emission-active fluorophore in light-emitting polymers. Along with the nonplanar and rigid emitter, the suppressed intramolecular charge-transfer effect and interchain disturbance can efficiently preserve the luminescence characteristics of the active center, resulting in high solid-state photoluminescence quantum yields of up to 89%. The amorphous polyimides exhibit excellent thermal properties, such as high glass transition temperature (T g) values (398 °C) and high thermal decomposition temperature (T d) values (538 °C). As far as we know, these luminescent polymer materials are of excellent heat resistance with the highest luminescence efficiency reported. The results have significant impact for the precise prediction of the optical properties of light-emitting polymers by appropriate monomer design, providing controllable ways for synthesizing high thermal stability polymeric materials with efficient fluorescence properties.

physics, and engineering. One of the key points lies in the development of flexible substrate materials and efficient packaging technology. The components of organic light-emitting devices (OLEDs) or organic photovoltaics (OPV), including the cathode materials and photoelectric conversion layer, are reactive; thus, thin films should encapsulate both the top and bottom surfaces of the devices to realize the desired property. [2-4] Barrier-coated plastic lids, ultrathin glasses, and vacuumdeposited thin films have been developed as thin-film encapsulation (TFE) approaches. [5] However, there are many issues with the current manufacturing methods for encapsulation films. The laser lift-off (LLO) process is widely used for flexible electronics manufacturing, requires evaporating each functional layer onto a substrate, then peeling the devices off the substrate using a laser; the product yield is high, but the productivity is low. In contrast, roll-to-roll (R2R) processing, which involves directly assembling the devices on a formed substrate, is more suitable for large-scale industrial production. [6,7] There are demanding performance requirements for the encapsulation film, such as light transmittance, flexibility, gas impermeability, and heat resistance. The encapsulation film in the direction of light transmission should be highly transparent. [8,9] The other functional layers in electronic devices can be fabricated with nanoscale thickness; thus, the flexibility of the completed devices mainly depends on the properties of the encapsulation materials. Encapsulation materials have gradually developed from rigid glass plates to flexible thin films in recent years. [6,10] The degree of gas permeability is the most important property of TFE materials because flexible electronics use reactive metals and organic matters in devices. It is generally required that the water vapor transmission rate (WVTR) and oxygen transmission rate (OTR) should be on the order of 10 −3-10 −6 g m −2 day −1 to provide flexible electronics to have a sufficient service life. [11,12] Furthermore, OLEDs, for example, use thin-film transistors (TFTs) to control brightness and grayscale. A flat/smooth surface (roughness average R a < 1 nm) is beneficial for the fabrication of its nanostructures, and as the manufacturing temperature of TFTs is very high, A good packing of flexible electronics is one of the most critical points to ensure its lifetime. However, efficient and straightforward packaging technology is still very challenging. In this work, a new strategy for preparing encapsulation film is reported by "enameling" a fusible glass layer on a polymer membrane. Careful consideration has been given to the materials properties and manufacturing process, and the obtained glass-coated polymer can combine the advantageous properties of polymers and inorganic materials unconventionally. The encapsulation films show exceptional overall properties, including transparency (<5% optical deterioration), flexibility (radius of curvature: 1.5 mm), and low ...

To develop stimuli-responsive polymers with highly comprehensive properties, sulfide-containing polyimides with relatively simple structures were designed and synthesized.

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