The unique blocking and immobilization of electrospinning nanofibers play an important role in tissue engineering, wound dressings, drug delivery systems and other fields.

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In this work, gold nanoparticles (AuNPs) and curcumin drug were incorporated in polyvinylidene fluoride (PVDF) nanofibers by electrospinning as a novel tissue engineering scaffold in nerve regeneration. The influence of AuNPs on the morphology, crystallinity, and drug release behavior of nanofiber membranes was characterized. A successful composite nanofiber membrane sample was observed by scanning electron microscopy (SEM). The addition of AuNPs showed the improved as well as prolonged cumulative release of the drug. The results indicated that PVDF–AuNPs nanofiber membrane could potentially be applied for nerve regeneration.

Polymer microspheres are widely used as carriers in delivering of hydrophobic or hydrophilic drugs. Surface coating of microspheres could be one of the attractive strategies to improve their properties. In this study, biodegradable polymer polylactic acid was dissolved in chloroform and non-solvent to electrospray porous polymer microspheres. The properties of the microspheres were improved by phosphoglyceride (P-P-Gly) coating, and its behavior was investigated by loading with curcumin as a model drug. The morphologies of different microspheres were observed by scanning electron microscope. The results indicated that the microspheres obtained by dimethyl sulfoxide as nonsolvent could form the structure with porous characteristics. X-ray diffraction, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy analysis revealed that P-P-Gly was successfully coated on the surface of the microspheres. In addition, the thermal behavior of the coated microspheres was investigated by differential scanning calorimetry. In vitro release experiments indicated that the drug-loaded microspheres showed a very gentle release trend, which was mainly due to the P-P-Gly coating could not completely cover the pores of the microspheres. The P-P-Gly-coated microspheres prepared in this work can be used as controlled release drug carriers with special needs.

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