Effects of the crystallinity on quercetin loaded the Eudragit L-100 electrospun nanofibers

Ao, Fen; Shen, Wen; Ge, Xuemei; Wang, Lan; Ning, Yuanlan; Ren, Huijun; Fan, Guodong; Huang, Menghui

doi:10.1016/j.colsurfb.2020.111264

Cited by 14 publications

(3 citation statements)

References 42 publications

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“…XRD was performed to further analyses the crystalline nature of QT coarse powder, lyophilized QT–NC, and QT–NC adsorbed in QT–NSSPE. As shown in Figure 7 , QT coarse powder exhibited sharp diffraction peaks at 2 θ value of 10.8°, 12.4°, and 27.4°, which was in accord with the document [ 48 ]. The presence of these sharp diffraction peaks indicated that QT was highly crystalline.…”

Section: Resultssupporting

confidence: 81%

Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin

et al. 2022

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The aim of this study was to develop a new drug nanocrystals self-stabilized Pickering emulsion (NSSPE) for improving oral bioavailability of quercetin (QT). Quercetin nanocrystal (QT–NC) was fabricated by high pressure homogenization method, and QT–NSSPE was then prepared by ultrasound method with QT–NC as solid particle stabilizer and optimized by Box-Behnken design. The optimized QT–NSSPE was characterized by fluorescence microscope (FM), scanning electron micrograph (SEM), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). The stability, in vitro release, and in vivo oral bioavailability of QT–NSSPE were also investigated. Results showed that the droplets of QT–NSSPE with the size of 10.29 ± 0.44 μm exhibited a core-shell structure consisting of a core of oil and a shell of QT–NC. QT–NSSPE has shown a great stability in droplets shape, size, creaming index, zeta potential, and QT content during 30 days storage at 4, 25, and 40 °C. In vitro release studies showed that QT–NSSPE performed a better dissolution behavior (65.88% within 24 h) as compared to QT–NC (50.71%) and QT coarse powder (20.15%). After oral administration, the AUC0–t of QT–NSSPE was increased by 2.76-times and 1.38 times compared with QT coarse powder and QT–NC. It could be concluded that NSSPE is a promising oral delivery system for improving the oral bioavailability of QT.

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Section: Resultssupporting

confidence: 81%

Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin

et al. 2022

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“…Sustained release refers to the continuous supply of drugs to the human body and is important for drug delivery systems. Unlike rapid or delayed release, sustained release provides a stable release rate to ensure a safe and stable drug concentration in the blood. − Sustained release systems have aroused great interests due to their good treatment efficiency by providing a constant delivery rate of drugs; moreover, these systems can achieve “few adverse reactions and one-time administration”. − …”

Section: Introductionmentioning

confidence: 99%

Electrospun PVP-Core/PHBV-Shell Fibers to Eliminate Tailing Off for an Improved Sustained Release of Curcumin

Liu

Chen

et al. 2021

Mol. Pharmaceutics

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Tailing off release in the sustained release of water-insoluble curcumin (Cur) is a significant challenge in the drug delivery system. As a novel solution, core–shell nanodrug containers have aroused many interests due to their potential improvement in drug-sustained release. In this work, a biodegradable polymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), and hydrophilic polyvinylpyrrolidone (PVP) were exploited as drug delivery carriers by coaxial electrospinning, and the core–shell drug-loaded fibers exhibited improved sustained release of Cur. A cylindrical morphology and a clear core–shell structure were observed by scanning and transmission electron microscopies. The X-ray diffraction pattern and infrared spectroscopy revealed that Cur existed in amorphous form due to its good compatibility with PHBV and PVP. The in vitro drug release curves confirmed that the core–shell container manipulated Cur in a faster drug release process than that in the traditional PHBV monolithic container. The combination of the material and structure forms a novel nanodrug container with a better sustained release of water-insoluble Cur. This strategy is beneficial for exploiting more functional biomedical materials to improve the drug release behavior.

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“…The low skin bioavailability of myricetin due to its poor water solubility and bad skin penetration is the biggest obstacle to its application, which is also a problem faced by most other flavonoids. Lots of publications have revealed that DDS can improve the physicochemical properties of flavonoids, such as quercetin [ 24 ], baicalein [ 25 ], and naringenin [ 26 ], to increase their water solubility and skin penetration. In the current study, the myricetin nanofiber formulation (MyNF) containing MYR, HPBCD, and PVP was successfully synthesized by the electrospinning process.…”

Section: Discussionmentioning

confidence: 99%

Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities

Lin

Yang

et al. 2023

Pharmaceutics

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Excessive exposure to ultraviolet radiation (UV) can induce oxidative stress through the over-production of reactive oxygen species (ROS) on the skin. Myricetin (MYR), a natural flavonoid compound, significantly inhibited UV-induced keratinocyte damage; however, its bioavailability is limited by its poor water solubility and inefficient skin penetration ability, which subsequently influences its biological activity. The purpose of the study was to develop a myricetin nanofibers (MyNF) system of hydroxypropyl-β-cyclodextrin (HPBCD)/polyvinylpyrrolidone K120 (PVP)-loaded with MYR that would enhance the water solubility and skin penetration by changing the physicochemical characteristics of MYR, including reducing the particle size, increasing the specific surface area, and amorphous transformation. The results also revealed that the MyNF can reduce cytotoxicity in HaCaT keratinocytes when compared with MYR; additionally, MyNF had better antioxidant and photoprotective activity than raw MYR for the UVB-induced HaCaT keratinocytes damage model due to the MyNF increased water solubility and permeability. In conclusion, our results demonstrate that MyNF is a safe, photostable, and thermostable topical ingredient of antioxidant nanofibers to enhance the skin penetration of MYR and prevent UVB-induced skin damage.

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Effects of the crystallinity on quercetin loaded the Eudragit L-100 electrospun nanofibers

Cited by 14 publications

References 42 publications

Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin

Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin

Electrospun PVP-Core/PHBV-Shell Fibers to Eliminate Tailing Off for an Improved Sustained Release of Curcumin

Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities

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