Electrospun PVP-Core/PHBV-Shell Fibers to Eliminate Tailing Off for an Improved Sustained Release of Curcumin

Abstract

Tailing off release in the sustained release of water-insoluble curcumin (Cur) is a significant challenge in the drug delivery system. As a novel solution, core–shell nanodrug containers have aroused many interests due to their potential improvement in drug-sustained release. In this work, a biodegradable polymer, poly­(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), and hydrophilic polyvinylpyrrolidone (PVP) were exploited as drug delivery carriers by coaxial electrospinning, and the core–shell drug-loaded fibers exhibited improved sustained release of Cur. A cylindrical morphology and a clear core–shell structure were observed by scanning and transmission electron microscopies. The X-ray diffraction pattern and infrared spectroscopy revealed that Cur existed in amorphous form due to its good compatibility with PHBV and PVP. The in vitro drug release curves confirmed that the core–shell container manipulated Cur in a faster drug release process than that in the traditional PHBV monolithic container. The combination of the material and structure forms a novel nanodrug container with a better sustained release of water-insoluble Cur. This strategy is beneficial for exploiting more functional biomedical materials to improve the drug release behavior.

Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications

“…In association, non-Fickian behavior was observed during curcumin release from the carrier system [134]. Other studies showed a detailed description of the in vitro release kinetics for curcumin [133,135,136].…”

“…In another study, polylactic acid/poly (ε-caprolactone) (PLA/PCL)-based electrospun mats were designed and loaded with curcumin, and its release behaviors were studied in vitro. Curcumin loading was maximized via the used polymer system, which showed effective cumulative release [133]. The results of another research study conveyed a new concept that curcumin-loaded chitosan microspheres linked to quantum dots is a potential candidate for use as a biocompatible carrier for the controlled drug delivery ability of curcumin.…”

Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium

“…DS is partially soluble in water, whose saturated solubility in PBS (pH = 7.0, 25 • C) is 1.13% [79]. As a popular non-steroidal anti-inflammatory drug, DS is available in a variety of dosage forms, particularly, there are many dosage forms for oral administration [80,81].…”

Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug

“…More than two-thirds of promising drugs on the market have limited biomedical functions due to dissolution problems [ 6 , 7 , 8 ]. Thus, many drug delivery systems are exploited to improve the bioavailability of poorly soluble drugs, such as nanoparticles [ 9 , 10 , 11 , 12 , 13 ], hydrogels [ 14 , 15 ], 3D printing [ 16 , 17 ], electrospun fibers [ 18 , 19 , 20 , 21 ], nanocapsules [ 22 ], and microspheres [ 23 ]. Among many drug delivery systems, electrospinning, a “one-step” process with cheap raw materials, shows remarkable potential in the delivery of poorly soluble drugs in recent studies.…”