Various kinds of controlled microtopographies can promote osteogenic differentiation of mesenchymal stem cells (MSCs), such as microgrooves, micropillars, and micropits. However, the optimal shape, size, and mechanism remain unclear. In this review, we summarize the relationship between the parameters of different microtopographies and the behavior of MSCs. Then, we try to reveal the potential mechanism between them. The results showed that the microgrooves with a width of 4–60 μm and ridge width <10 μm, micropillars with parameters less than 10 μm, and square micropits had the full potential to promote osteogenic differentiation of MSCs, while the micromorphology of the same size could induce larger focal adhesions (FAs), well-organized cytoskeleton, and superior cell areas. Therefore, such events are possibly mediated by microtopography-induced mechanotransduction pathways.
Implant-supported cement-screw-retained crowns combine the advantages of screw-retained and cement-retained crowns. However, the occlusal screw access hole interrupts porcelain integrity, which may result in porcelain cracks or fractures. There is insufficient scientific evidence to prove that screw access holes affect the fracture load of implant-supported monolithic zirconia crowns. In this study, we investigated the effects of the screw access hole and its preparation technique on the fracture load of implant-supported monolithic zirconia single crown. The crowns were designed for the maxillary right first premolar. Three techniques analysed for screw access hole preparations included computer-aided designed/ computer-aided manufactured (CAD/CAM) before sintering, manually prepared after sintering, and then resintering. Our findings show that the screw access holes and preparation techniques have no significant effects on the fracture load of implant-supported monolithic zirconia single crown. On the other hand, the screw access hole preparation techniques affect failure initiation in implant-supported monolithic zirconia single crown.
Dental or tooth wear is a physiological process in the life cycle of teeth. Loss of the occlusal surface may cause excessive tooth wear. Several factors may contribute to tooth wear with different intensities and duration in the oral cavity. The oral cavity is generally compared to a tribological system to determine the various types of wear between teeth and restorative materials and assess the amount of dental wear. However, it is challenging to investigate in vitro and in vivo wear owing to the complexity of tooth wear; thus, a clear correlation between in vitro and in vivo data could not be established. This review is aimed at providing an insight into the etiology of tooth wear and tribological investigations in dentistry.
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