Estimates of the depression prevalence among Chinese university students vary considerably across studies. This systematic review and meta-analysis aimed to comprehensively analyze the depression prevalence among Chinese university students. We searched four electronic databases with the search terms of depression, China, university student, and questionnaire. Studies reporting depression among Chinese university students were included in the analysis. Two reviewers independently extracted the data and assessed the qualities of the studies. The package of “meta” in R Foundation for Statistical Computing was used to calculate an overall proportion in a random-effects model with 95% confidence intervals. Subgroup analysis was conducted to analyze the influencing factors on the depression prevalence. Any conflict in the data analysis was discussed by all the reviewers. A total of 113 studies were included in the meta-analysis. The overall prevalence of depression among Chinese university students was shown to be 28.4% (n = 185,787), with 95%CI from 25.7 to 31.2%. The overall depression prevalence among Chinese university students was still relatively high. More efforts need to be done to provide better mental healthcare to university students in China.
BackgroundThe circulating concentration of 25(OH)D is widely applied to indicate the vitamin D status, as the directly metabolic genes of 25(OH)D, CYP2R1, and CYP27B1 are associated with the concentration of 25(OH)D. However, the contributions of allelic transmission disequilibrium of single nucleotide polymorphisms (SNPs) in these genes to vitamin D deficiency remain unclear. We aimed at investigating the family‐based association between SNPs of CYP2R1 and CYP27B1 and vitamin D deficiency.MethodFirst, SNPs selected in family‐based study were screened by a pilot case‐control study. Second, allelic transmissions of the selected SNPs were investigated with family‐based study (n = 880). Finally, associations between selected SNPs and the concentration of 25(OH)D were verified in siblings (n = 120).ResultsThe results of the pilot case‐control study indicated that both CT and TT genotypes of rs4646536 in CYP27B1 could increase the susceptibility of vitamin D deficiency when compared with CC genotype. The adjusted ORs were 2.846 (95%CI 1.312‐6.174, P = 0.008) and 2.609 (95%CI 1.197‐5.687, P = 0.016), respectively. Furthermore, the results of family‐based association test suggested that there was transmission disequilibrium for allele T of rs4646536 in vitamin D deficiency families. In addition, the concentration of 25(OH)D3 for CC genotype was higher than CT genotype between siblings (P = 0.016).ConclusionsTransmission disequilibrium of allele T of rs4646536 is associated with vitamin D deficiency.
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