Poyang Lake is China's largest freshwater lake with a high degree of spatio-temporal variation. The lake has shrunk in size in recent years, resulting in significant hydrological, ecological and economic consequences. It remains unknown whether the shrinkage is a trend or a regime shift, which is of high importance for policymakers as it may lead to different decisions. This study constructed a four-decade record of the lake area using multi-temporal satellite images and hydrological data. The Mann-Kendall analysis revealed a decreasing trend of Poyang Lake but it was statistically insignificant. The Rodionov sequential approach disclosed an abrupt change of the lake in 2006, implying a regime shift. Basically, the lake change was a synthetic result of precipitation, evapotranspiration and outflow discharge. However, precipitation and outflow did not show any significant trend or abrupt change, and evapotranspiration had an increasing trend in addition to an abrupt change in 1998. The trigger for the recent lake declines was principally ascribed to a weakened blocking effect of the Yangtze River. The findings provide an example of hydrologic non-stationarity and are valuable for effective promotion of climate adaptation and water resource management.

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The aesthetic surgeon may occasionally be consulted by a patient who wishes to discuss what can be done for the scars of self-inflicted wounds on the forearms. These scars are popularly referred to as "hesitation marks" or "suicide gestures." Unlike patients suffering from factitial ulcers or Münchhausen syndrome, these patients will admit to the physician that the scars are the result of self-inflicted wounds. These scars often consist of multiple, parallel, white lines extending up and down the forearms (usually volar surface), with more on the nondominant side. Although the pattern of these scars is apparently what drives these patients to the aesthetic surgeon for relief (because even lay people identify these scars as self-inflicted suicide marks), the authors propose a new and deeper motivation for surgery. Recent experiences with three of these patients resulted in an epiphany that prompted this report. Once the symbolic meaning of these scars was broached, a torrent of thoughts and theories followed. This article will recount these three cases and present a central thesis for this type of self-inflicted injury. A proposal for the proper surgical treatment of this condition will be offered. Uniquely, two of the patients will relate their own stories and propose guidelines and warnings for the aesthetic surgeon.

Improper use of land resources may result in severe soil salinization. Timely monitoring and early warning of soil salinity is in urgent need for sustainable development. This paper addresses the possibility and potential of Advanced Land Imager (ALI) for mapping soil salinity. In situ field spectra and soil salinity data were collected in the Yellow River Delta, China. Statistical analysis demonstrated the importance of ALI blue and near infrared (NIR) bands for soil salinity. A partial least square regression (PLSR) model was established between soil salinity and ALI-convolved field spectra. The model estimated soil salinity with a R 2 (coefficient of determination), RPD (ratio of prediction to deviation), bias, standard deviation (SD) and root mean square error (RMSE) of 0.749, 3.584, 0.036 g·kg . The model was then applied to atmospherically corrected ALI data. Soil salinity was underestimated for moderately (soil salinity within 2-4 g·kg −1) and highly saline (soil salinity >4 g·kg sensing pixels was probably the major source responsible for the underestimation. Our study demonstrates the effectiveness of PLSR model in retrieving soil salinity from new-generation multi-spectral sensors. This is very valuable for achieving worldwide soil salinity mapping with low cost and considerable accuracy.

Keloid is a skin fibrotic disease with the characteristics of recurrence and invasion, its pathogenesis still remains unrevealed. The epithelial-mesenchymal transition (EMT) is critical for wound healing, fibrosis, recurrence, and invasion of cancer. We sought to investigate the EMT in keloid and the mechanism through which the EMT regulates keloid formation. In keloid tissues, the expressions of EMT-associated markers and transforming growth factor (TGF)-β1/Smad3 signaling were examined by immunohistochemistry. In the keloid epidermis and dermal tissue, the expressions of genes related to the regulation of skin homeostasis, fibroblast growth factor receptor 2 (FGFR2) and p63, were analyzed using quantitative real-time polymerase chain reaction. The results showed that accompanying the loss of the epithelial marker E-cadherin and the gain of the mesenchymal markers fibroblast-specific protein 1 (FSP1) and vimentin in epithelial cells from epidermis and skin appendages, and in endothelial cells from dermal microvessels, enhanced TGF-β1 expression and Smad3 phosphorylation were noted in keloid tissues. Moreover, alternative splicing of the FGFR2 gene switched the predominantly expressed isoform from FGFR2-IIIb to -IIIc, concomitant with the decreased expression of ΔNp63 and TAp63, which changes might partially account for abnormal epidermis and appendages in keloids. In addition, we found that TGF-β1-induced hair follicle outer root sheath keratinocytes (ORSKs) and normal skin epithelial cells underwent EMT in vitro with ORSKs exhibiting more obvious EMT changes and more similar expression profiles for EMT-associated and skin homeostasis-related genes as in keloid tissues, suggesting that ORSKs might play crucial roles in the EMT in keloids. Our study provided insights into the molecular mechanisms mediating the EMT pathogenesis of keloids.

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