Six new compounds, including one tetralone (1), two xanthones (2 and 3), one flavan derivative (4), and two nor-diterpenoids (7 and 8), with two known flavan derivatives (5 and 6) and one known olefine acid (9) were isolated from the whole bodies of Kromopolites svenhedini (Verhoeff). All the structures of new compounds were determined by 1D and 2D nuclear magnetic resonance (NMR) and other spectroscopic methods, as well as computational methods. Part of the compounds were evaluated for their biological properties against the mouse pancreatic cancer cell line and inhibitory effects on iNOS and COX-2.
Six new compounds, including a tetralone 1, two xanthones 2 and 3, a flavan derivative 4, and two nor-diterpenoids 7 and 8, accompanied by two known flavan derivatives 5 and 6 and a known olefine acid (9) were isolated from whole bodies of Kronopolites svenhedini (Verhoeff). The structures of the new compounds were determined by 1D and 2D nuclear magnetic resonance (NMR) and other spectroscopic methods, as well as computational methods. Selected compounds were evaluated for their biological properties against a mouse pancreatic cancer cell line and inhibitory effects on iNOS and COX-2 in RAW264.7 cells.
Zizhines V, W, Y, Z, (�)-zizhines X, and Z1À Z3, and (�)-ganosinensol L, thirteen new compounds including four pairs of enantiomers and a known compound (À )-ganosinensol L, were isolated from the fruiting bodies of Ganoderma sinensis. Their structures were identified by spectroscopic, computational methods, and CD (circular dichroism spectroscopy) comparisons. Zizhines VÀ Z and Z1À Z3 are meroterpenoids consisting of the phenolic and the terpenoidal parts. All the compounds except zizhine Z3 bear a common trans-p-hydroxycinnamoyl group. Biological evaluation shows that (À )-zizhine Z1 inhibits cell migration in the MDA-MB-231 cell lines. The present study discloses the chemical profiling of G. sinensis and paves the way for its development as functional products to benefit chronic disorders.
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