Isolation and Characterization of trans‐p‐Hydroxycinnamoyl Meroterpenoids from Ganoderma sinensis

Abstract

Zizhines V, W, Y, Z, (�)-zizhines X, and Z1À Z3, and (�)-ganosinensol L, thirteen new compounds including four pairs of enantiomers and a known compound (À )-ganosinensol L, were isolated from the fruiting bodies of Ganoderma sinensis. Their structures were identified by spectroscopic, computational methods, and CD (circular dichroism spectroscopy) comparisons. Zizhines VÀ Z and Z1À Z3 are meroterpenoids consisting of the phenolic and the terpenoidal parts. All the compounds except zizhine Z3 bear a common trans-p-hydroxycinnamoyl group. Biological evaluation shows that (À )-zizhine Z1 inhibits cell migration in the MDA-MB-231 cell lines. The present study discloses the chemical profiling of G. sinensis and paves the way for its development as functional products to benefit chronic disorders.