Geographic distance and geographical barriers likely play a considerable role in structuring genetic variation in species, although some migratory species may have less phylogeographic structure on a smaller spatial scale. Here, genetic diversity and the phylogenetic structure among geographical populations of the yellow-spined bamboo locust, Ceracris kiangsu, were examined with 16S rDNA and amplified fragment length polymorphisms (AFLPs). In this study, no conspicuous phylogeographical structure was discovered from either Maximum parsimony (MP) and Neighbor-joining (NJ) phylogenetic analyses. The effect of geographical isolation was not conspicuous on a large spatial scale.At smaller spatial scales local diversity of some populations within mountainous areas were detected using Nei's genetic distance and AMOVA. There is a high level of genetic diversity and a low genetic differentiation among populations in the C. kiangsu of South and Southeast China. Our analyses indicate that C. kiangsu is a monophyletic group. Our results also support the hypothesis that the C. kiangsu population is in a primary differentiation stage. Given the mismatch distribution, it is likely that a population expansion in C. kiangsu occurred about 0.242 Ma during the Quaternary interglaciation. Based on historical reports, we conjecture that human activities had significant impacts on the C. kiangsu gene flow.
Nasopharyngeal carcinoma (NPC) is prevalent among populations from southern China and is influenced by both genetic and environmental risk factors. The monocyte chemoattractant protein‐1 (MCP‐1), a member of cysteine‐cysteine chemokine family, plays critical roles in cancers. A polymorphism within the MCP‐1 promoter, rs1024611, has been shown to be significantly associated with the risk of several cancers. Our purpose was to assess the role of rs1024611 in NPC susceptibility. By polymerase chain reaction‐restriction fragment length polymorphism method, we genotyped rs1024611 in 593 patients with NPC (cases) and 480 cancer‐free subjects (controls) among Guangxi population from southern China. We observed that the G allele of rs1024611 was significantly associated with the increased risk of NPC in an additive model and dominant model, respectively (P = 0.018 and 0.010, odds ratio = 1.25 and 1.41, respectively). No appreciable variation of the effects was found across the subgroups stratified by age, sex, nationality, smoking and drinking status, and smoking level. In addition, significantly higher messenger RNA (mRNA) expression level of MCP‐1 was observed in NPC tissues than that in normal nasopharyngeal tissues, and the G allele of rs1024611 was significantly associated with elevated mRNA expression level of MCP‐1 in Epstein‐Barr virus‐transformed lymphocytes. In conclusion, our findings suggested that rs1024611 at the MCP‐1 promoter may be a risk factor for NPC. Further studies with larger sample size are necessary to confirm these findings.
Damage detection by the wavelet transform of the fundamental vibration mode receives
much attention recently. However, the higher vibration modes were hardly discussed in past
literatures. As we know they are more sensitive to the crack comparing with the fundamental mode,
which bring abundant damage information. The objective of this study is to show that the first four
modes are available using wavelet transform for crack parameter identification. Specially, using the
higher mode could result in an excellent quality of crack identification when the mode data was
contaminated by noise. But too higher modes have possibly adverse effects on the quality of crack
detection.
Research shows that the redox complementarity and synergism etc. amidst the ingredients of heterogeneous catalysts can enhance the performance of the catalyst. In this research, a porous nanosheet CuMoO4@Co3O4 electrocatalyst...
A four span curved HcontinuousH HboxH-girder bridge is used as an engineering example to investigate the effect of radius of curvature on the seismic response of curved bridge. Numerical models with different radii of curvature are created using the finite element analysis program Midas/Civil. The calculation results obtained from response spectrum method show that radius of curvature is an important parameter to curved bridge. When the radius of curvature is large enough, the relationship between seismic response of main girder and radius is approximately linearity, while nonlinear variation is obtained when theradius is not too large. Finally, conclusions are made that seismic design of Hstraight bridgeH unHfoldHed from curved bridge which radius of curvature is specified could Hsatisfy the engineering Hrequirement.
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