MNs have been developed for various applications such as drug delivery, cosmetic, diagnosis and biosensing. To meet the requirements of MNs used in these areas, numerous materials have been used...
To
alleviate the dilemma of drug administration in Alzheimer’s
disease (AD) patients, it is of great significance to develop a new
drug delivery system. In this study, a subcutaneously implanted microneedle
(MN) device with a swellable gelatin methacryloyl (GelMA) needle body
and a dissolvable polyvinyl alcohol (PVA) backing layer was designed.
The backing layer quickly dissolved once the MN was introduced into
the subcutaneous, and the hydrogel needles were implanted in the subcutaneous
to enable prolonged drug release. Compared with oral administration,
the MN system offers the benefits of a high administration rate, a
fast onset of effect, and a longer duration of action. By detecting
the concentration of acetylcholine (ACH) and Aβ 1–42,
it was found that MN administration exhibited a stronger therapeutic
effect. The biological safety of the MN system was also assessed,
and no obvious signs of hemolysis, cytotoxicity, and inflammatory
reaction were observed. Together, these findings suggested that the
MN system is a convenient, efficient, and safe method of delivering
donepezil hydrochloride (DPH) and may provide AD patients with a novel
medicine administration option.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.