Thermosensitive hydrogel microneedles for controlled transdermal drug delivery

Li, Jun You; Feng, Yun Hao; He, Yu Ting; Hu, Liu Fu; Liang, Ling; Zhao, Ze Qiang; Chen, Bo Zhi; Guo, Xin Dong

doi:10.1016/j.actbio.2022.08.061

Cited by 46 publications

(19 citation statements)

References 59 publications

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“…These microneedles provided rapid separation and effective drug release within seconds. This microneedle system significantly enhanced the transdermal delivery of insulin across the skin of diabetic mice, providing a substantial hypoglycemic effect [ 227 ].…”

Section: Microneedle Types For Biopharmaceutical Deliverymentioning

confidence: 99%

Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals

Nguyen

2023

Pharmaceutics

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Transdermal delivery provides numerous benefits over conventional routes of administration. However, this strategy is generally limited to a few molecules with specific physicochemical properties (low molecular weight, high potency, and moderate lipophilicity) due to the barrier function of the stratum corneum layer. Researchers have developed several physical enhancement techniques to expand the applications of the transdermal field; among these, microneedle technology has recently emerged as a promising platform to deliver therapeutic agents of any size into and across the skin. Typically, hydrophilic biomolecules cannot penetrate the skin by passive diffusion. Microneedle insertion disrupts skin integrity and compromises its protective function, thus creating pathways (microchannels) for enhanced permeation of macromolecules. Microneedles not only improve stability but also enhance skin delivery of various biomolecules. Academic institutions and industrial companies have invested substantial resources in the development of microneedle systems for biopharmaceutical delivery. This review article summarizes the most recent research to provide a comprehensive discussion about microneedle-mediated delivery of macromolecules, covering various topics from the introduction of the skin, transdermal delivery, microneedles, and biopharmaceuticals (current status, conventional administration, and stability issues), to different microneedle types, clinical trials, safety and acceptability of microneedles, manufacturing and regulatory issues, and the future of microneedle technology.

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Section: Microneedle Types For Biopharmaceutical Deliverymentioning

confidence: 99%

Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals

Nguyen

2023

Pharmaceutics

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“…When MNs are partially inserted into the skin surface, they will absorb water and swell. Due to the above characteristics, based on the osmotic pressure difference or temperature difference between ISF and the MN matrix, after fully absorbing the ISF, the pores between the polymer materials are opened larger, leading to drug release [ 50 – 53 ]. It is also not negligible that the porous characteristics of hydrogel MNs make it possible to adjust the release rate of drugs through different degrees of cross-linking, which has more advantages than soluble MNs in drug delivery [ 54 – 56 ].…”

Section: The Different Types Of Mns In the Treatment Of Tumorsmentioning

confidence: 99%

“…In recent years, to deal with the occurrence of various skin cancers, synergy strategy [ 85 , 86 ], drug function modification strategy [ 87 ], spatiotemporal controllable drug release strategy [ 50 , 73 , 88 ], local targeted drug delivery strategy, [ 5 , 89 ], and other methods have been developed. Among them, the local targeted therapy strategy has become a potential treatment mode due to its remarkable drug concentration and few side effects.…”

Section: Mn-mediated Treatment and Diagnosis Of Superficial Tumorsmentioning

confidence: 99%

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

Wang

et al. 2023

Drug Deliv. and Transl. Res.

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Superficial tumors are still challenging to overcome due to the high risk and toxicity of surgery and conventional chemotherapy. Microneedles (MNs) are widely used in the treatment of superficial skin tumors (SST) due to the high penetration rate of the stratum corneum (SC), excellent biocompatibility, simple preparation process, high patient compliance, and minimal invasion. Most importantly, MNs can provide not only efficient and rarely painful delivery carriers, but also combine multi-model strategies with photothermal therapy (PTT), immunotherapy, and gene therapy for synergistic efficacy. To promote an in-depth understanding of their superiorities, this paper systematically summarized the latest application progress of MNs in the treatment of SST by delivering various types of photosensitizers, immune signal molecules, genes, and chemotherapy drugs. Just as important, the advantages, limitations, and drug release mechanisms of MNs based on different materials are introduced in the paper. In addition, the application of MN technology to clinical practice is the ultimate goal of all the work. The obstacles and possible difficulties in expanding the production of MNs and achieving clinical transformation are briefly discussed in this paper. To be anticipated, our work will provide new insights into the precise and rarely painful treatment of SST in the future. Graphical Abstract

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“…22 Among the diversity of temperature-responsive materials, poly( N -isopropylacrylamide) (PNIPAM) is widely used due to the volume of chemically crosslinked PNIPAM hydrogel decreasing significantly with increasing temperature, endowing PNIPAM hydrogels with strong potential for temperature sensing. 23,24 Besides, the low critical solution temperature (LCST) of PNIPAM is approximately 33 °C, which is close to the surface temperature of the human body, making it suitable for body temperature monitoring. The superior properties and abundance of derivatives of PNIPAM give it wide applications, including actuation, sensing, separation, drug and gene delivery and tissue engineering.…”

Section: Introductionmentioning

confidence: 99%