A novel polychloromethylation/acyloxylation of 1,6-enynes with chloroalkanes and diacyl peroxides through dual roles designs to prepare 2-pyrrolidinone derivatives with polychloromethyl units has been developed by the use of inexpensive copper...
A novel method for assembling pyrrolidine-2,4-diones from 1,5-enenitriles and acetone/acetonitrile via a cyclization/hydrolysis has been established under metal catalyst- and base-free conditions, with Oxone as a green oxidant and H2O as an additive at 90-110 ℃. This strategy is highlighted by cyclization/hydrolysis of alkyl cyanides, achieving direct C(sp3)–H oxidative functionalization, and giving full conversion of the substrates with excellent functional group compatibility.
A novel cyclization/hydrolysis of 1,5-enenitriles for the synthesis of valuable pyrrolidine-2,4-diones in aqueous phase using I2 as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant is reported. In the...
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