The polychloromethylation/acyloxylation of 1,6-enynes with chloroalkanes and diacyl peroxides through dual-role designs

Abstract

A novel polychloromethylation/acyloxylation of 1,6-enynes with chloroalkanes and diacyl peroxides through dual roles designs to prepare 2-pyrrolidinone derivatives with polychloromethyl units has been developed by the use of inexpensive copper...

Recent Advances in Cyclization Reactions of 1,6‐Enynes

“…In 2022, a copper-catalyzed polychloromethylation/ acyloxylation of 1,6-enynes has been disclosed by the Lei and Wei group through dual-role design, which provided a simple approach to a sequence of 2pyrrolidinone derivatives bearing polychloromethyl units in moderate to good yields (Scheme 41). [36] This copper-catalyzed protocol, which employed chloroalkane as polychloromethylation reagent and solvent, iacyl peroxidesa as radical initiator and acyloxylation reagent, furnished a distinct method of accessing polycyclic compounds under mild conditions.…”

Ultrasound-promoted synthesis of a copper–iron-based catalyst for the microwave-assisted acyloxylation of 1,4-dioxane and cyclohexene

“…8–10 In this scenario, the development of new catalysts that enables the introduction of oxygenated functions into C(sp 3 )–H bonds is a challenge undertaken by many research groups. 11–15…”