Previously we have demonstrated [1] that trihalide substituents of tris [(2-diethylbenzylammonio)ethyl] isocyanurates exhibit a high curarelike activity. The results of pharmacological investigations indicate that 1,3,5-tris[(2-benzyldiethylammonio)ethyl]-1,3,5-triazine-2,4,6( 1H,3H,5H)-tr ione tribromide (I) named "isocyuronium bromide" can be used in medicine as a myorelaxation drug. This compound was synthesized by way of interaction between cyanuric chloride and sodium 2-(diethylamino)ethylate, followed by thermal isomerization of the resulting cyanurate to isocyanurate (II) and quaternization of the latter ester by benzyl bromide. CI
l lH-Dibenz[b, e]azepines (I) are known to possess a broad spectrum of biological activity. This class of substances includes, in particular, efficient neuroleptics and antidepressants [I, 2].In continuation of our investigations devoted to the synthesis of new effective antidepressants [3, 4], we have synthesized a series of previously unreported salts of dibenz[b,f]-1,4-ox(thia)azepine and characterized them with respect to optical and some other properties.Protonated salts (IIa-IIg, III-VIII) were obtained in a high yield by interactions of bases I with the corresponding acids in an inert solvent at 10-40~
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.