Previously we have demonstrated [1] that trihalide substituents of tris [(2-diethylbenzylammonio)ethyl] isocyanurates exhibit a high curarelike activity. The results of pharmacological investigations indicate that 1,3,5-tris[(2-benzyldiethylammonio)ethyl]-1,3,5-triazine-2,4,6( 1H,3H,5H)-tr ione tribromide (I) named "isocyuronium bromide" can be used in medicine as a myorelaxation drug. This compound was synthesized by way of interaction between cyanuric chloride and sodium 2-(diethylamino)ethylate, followed by thermal isomerization of the resulting cyanurate to isocyanurate (II) and quaternization of the latter ester by benzyl bromide. CI
Разработана экспрессная и чувствительная методика количественного определения метилдопы в плазме крови с применением ВЭЖХ-МС/МС. Динамический диапазон измерения концентраций составил 0,02-3,00 мкг/мл. Данная методика использована для проведения исследования фармакокинетики таблетированной формы метилдопы.Ключевые слова: метилдопа, ВЭЖХ-МС/МС, плазма, стабилизация, фармакокинетика.
Quinta-Analytica, YaroslavlWe developed a rapid and sensitive method for quantifying plasma concentrations of methyldopa using HPLC-MS/MS. The range of concentration measurements was 0,02-3,00 g/ml. The method was applied for pharmacokinetic study of methyldopa tablet formulations.
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