In vivo cellular targeted imaging of activated HSCs in liver fibrosis using c(RGDyC)-USPIO targeting α(v)β(3) integrins was feasible using a clinical 1.5-Tesla MR system.

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Heterostructure devices based on two-dimensional materials have been under intensive study due to their intriguing electrical and optical properties. One key factor in understanding these devices is their nanometer-scale band profiles, which is challenging to obtain in devices. Here, we use a technique named contact-mode scanning tunneling spectroscopy to directly visualize the band profiles of MoS2/WSe2 heterostructure devices at different gate voltages with nanometer resolution. The long-held view of a conventional p–n junction in the MoS2/WSe2 heterostructure is reexamined. Due to strong inter- and intralayer charge transfer, the MoS2 layer in contact with WSe2 is found to convert from n-type to p-type, and a series of gate-tunable p–n and p–p + junctions are developed in the devices. Highly conductive edges are also discovered which could strongly affect the device properties.

Abstract. Objectives: This report presents toxicological profile available on a superparamagnetic iron oxide (SPIO) nanoparticle in vivo. Materials and Methods: Single-and repeat-dose toxicity studies were performed with SPIO given subcutaneously in mice. Results: The SPIO nanoparticle exhibited a low toxicity profile, with no treatment-related deaths and few transient clinical signs. SPIO was taken up and distributed in heart, spleen, liver, lung, kidney, brain decreasingly within 24 hours after injection. After repeated injections for 10days, the accumulation of iron on organs studied is slight, indicating that iron is eliminated fast at 100mg/kg given subcutaneously in mice. At histopathology, no iron-positive pigment was observed in macrophages of multiple organs (mainly heart, liver, spleen, lung, kidney, brain). Conclusion:The results of most of the studies demonstrated low hazard potential in mice following acute injection to the SPIO nanoparticle tested in this program. All effects observed are unlikely to occur in clinical practice because of the single low dosing in humans. IntroductionRecently, medical applications of nanotechnology have attracted growing interest. Until now, a large number of new nanotechnology-based concepts for therapeutic and diagnostic medicines have emerged, and their feasibility has been demonstrated [1] . However, the risk associated with passive

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In this paper, two-dimensional percolation lattices are applied to describe wireless propagation environment, and stochastic rays are employed to model the trajectories of radio waves. We first derive the probability that a stochastic ray undergoes certain number of collisions at a specific spatial location. Three classes of stochastic rays with different constraint conditions are considered: stochastic rays of random walks, and generic stochastic rays with two different anomalous levels. Subsequently, we obtain the closed-form formulation of mean received power of radio waves under non line-of-sight conditions for each class of stochastic ray. Specifically, the determination of model parameters and the effects of lattice structures on the path loss are investigated. The theoretical results are validated by comparison with experimental data.

Physiologically relevant electrical microenvironments play an indispensable role in manipulating bone metabolism. Although implanted biomaterials that simulate the electrical properties of natural tissues using conductive or piezoelectric materials have been introduced in the field of bone regeneration, the application of electret materials to provide stable and persistent electrical stimulation has rarely been studied in biomaterial design. In this study, a silicon dioxide electret-incorporated poly­(dimethylsiloxane) (SiO2/PDMS) composite electroactive membrane was designed and fabricated to explore its bone regeneration efficacy. SiO2 electrets were homogeneously dispersed in the PDMS matrix, and sandwich-like composite membranes were fabricated using a facile layer-by-layer blade-coating method. Following the encapsulation, electret polarization was conducted to obtain the electreted composite membranes. The surface potential of the composite membrane could be adjusted to a bone-promotive biopotential by tuning the electret concentration, and the prepared membranes exhibited favorable electrical stability during an observation period of up to 42 days. In vitro biological experiments indicated that the electreted SiO2/PDMS membrane promoted cellular activity and osteogenic differentiation of mesenchymal stem cells. In vivo, the electreted composite membrane remarkably facilitated bone regeneration through persistent endogenous electrical stimulation. These findings suggest that the electreted sandwich-like membranes, which maintain a stable and physiological electrical microenvironment, are promising candidates for enhancing bone regeneration.