Complementary and synergistic effects on osteogenic and angiogenic properties of copper-incorporated silicocarnotite bioceramic: In vitro and in vivo studies

Ultrathin 2D Inorganic Ancient Pigment Decorated 3D‐Printing Scaffold Enables Photonic Hyperthermia of Osteosarcoma in NIR‐II Biowindow and Concurrently Augments Bone Regeneration

“…[ 21 ] Especially, Cu‐containing chalcogenides have featured preferable popularity among numerous PTAs attributing to their intense NIR absorption capability. [ 22 , 23 ] Besides, it is noteworthy that Cu 2+ can not only inhibit cancer cells, [ 24 , 25 ] but also enhance osteogenesis, [ 26 , 27 , 28 ] which is more valuable to be introduced into the treatment of OS compared with the commonly studied PTAs that only possess photothermal conversion abilities.…”

Bioinspired Redwood‐Like Scaffolds Coordinated by In Situ‐Generated Silica‐Containing Hybrid Nanocoatings Promote Angiogenesis and Osteogenesis both In Vitro and In Vivo

“…The release concentration of Ca and Si ions increased from 59.8 ± 1.1 and 44.1 ± 2.4 μg mL −1 after 1 day of immersion to 141.4 ± 22.8 and 71.9 ± 1.9 μg mL −1 after 28 days of immersion, respectively, which were in the range considered effective for guiding bone regeneration. [23,36] Additionally, the pH value of the discarded solution from SCPN-HS-RW was stable at ≈7.4 throughout the immersion time (Figure S3e, Supporting Information). Recent evidence suggests that bioactive Ca and Si ions released from scaffolds have essential roles in angiogenesis, osteogenesis, and mineralization by activating the calcium signaling pathway and MAPK and PI3K signaling pathways, respectively, during the process of bone repair.…”

“…The statistical data also showed a markedly higher number of migrated cells in the SCPN-HS-RW group than in all other groups throughout the culture period (Figure S6a,b, Supporting Information), which is in line with previous work reporting the stimulating role of Si-containing biomaterials on cell migration. [36,47] Further research has also demonstrated that the incorporation of chemokines such as Si into biomaterials can efficiently promote the migration and tube formation of endothelial cells and even provides results comparable to those of VEGF. [48] Accordingly, the moderate Si ion concentrations released by SCPN-HS-RW are beneficial to promote the migration of both BMSCs and HUVECs.…”

“…Additionally, studies have shown that Si ions can promote the expression of VEGF in HUVECs (endogenous) and activate HIF-1𝛼 to directly and indirectly enhance angiogenic activity. [36] Therefore, the expression of two key angiogenesis-related markers, HIF-1𝛼 and VEGF, was assessed by qRT-PCR analysis (Figure 6c,d). As expected, after 7 days of culture, the expression of HIF-1𝛼 and VEGF was significantly higher in the SCPN-HS-RW group than in the other scaffold groups, suggesting good in vitro angiogenic activities.…”

Anisotropic expansion effect of Sr doping on the crystal structure of hydroxyapatite

“…1,2 Natural bone contains a variety of trace elements, such as Sr, Si, Mg, Zn, F, etc., which have important biochemical functions in human hard tissues. [3][4][5][6][7] Among these substituents, strontium (Sr) is one of the most beneficial and desirable elements due to its positive effects on bone formation. Sr could enhance the replication of osteoblasts and stimulate new bone formation.…”