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Extracellular vesicles (EVs) are membrane-derived heterogeneous vesicles that mediate intercellular communications. They have recently been considered as ideal vehicles for drug-delivery systems, and immune cells are suggested as a potential source for drug-loaded EVs. In this study, we investigated the possibility of neutrophils as a source for drug-loaded EVs. Neutrophil-like differentiated human promyelocytic leukemia cells (dHL-60) produced massive amounts of EVs within 1 h. The dHL-60 cells are also easily loaded with various cargoes such as antibiotics (penicillin), anticancer drug (paclitaxel), chemoattractant (MCP-1), miRNA, and Cas9. The EVs derived from the dHL-60 cells showed efficient incorporation of these cargoes and significant effector functions, such as bactericidal activity, monocyte chemotaxis, and macrophage polarization. Our results suggest that neutrophils or neutrophil-like promyelocytic cells could be an attractive source for drug-delivery EVs.

The character industry is a high value-added industry, and is one of the strategic industries to be fostered. However, the character industry is struggling due to the lack of national consensus on the importance and value of the character industry. Therefore, in order to resolve this issue, the study used the character Input-Output Table of year 2009 of korea to analyze how much the character industry(Toys and games, Models and decorations) contributes to the national economy by measuring economic spreading effects of character industry on national economy. The results shows that character industry shows that production inducement coefficient is column 1.602, row 1.007, index of the sensitivity of dispersion is 0.543, Index of the power of dispersion is 0.864, value-added coefficient is 0.620, income inducement coefficient is 0.334, tax inducement coefficient is 0.066, employment inducement coefficient is 0.008.