Positron emission tomography imaging of β-amyloid (Aβ) plaques has proven useful in the diagnosis of Alzheimer’s disease. A previous study from our group showed that 4′-
O
-[
18
F]fluoropropylcurcumin has poor brain permeability, which is thought to be due to its rapid metabolism. In this study, we synthesized difluoroboron complexes of fluorine-substituted curcumin derivatives (
1
–
4
) and selected one of them based on the
in vitro
binding assays. The selected ligand
2
was found to distinctively stain Aβ plaques in APP/PS1 transgenic mouse brain sections. Radioligand [
18
F]
2
was synthesized via a two-step reaction consisting of [
18
F]fluorination and subsequent aldol condensation. Biodistribution and metabolism studies indicated that radioligand [
18
F]
2
was converted to polar radioactive products and trapped in the normal mouse brain. In contrast, optical images of mice acquired after injection of
2
showed moderate fluorescence signal intensity in the mouse brain at 2 min with a decrease in the signal within 30 min. In the
ex vivo
optical images, the fluorescence signals in major tissues disappeared within 30 min. Taken together, these results suggest that [
18
F]
2
may be converted to polar
18
F-labeled blue-shifted fluorescent products. Further structural modifications are thus needed to render the radioligand metabolically stable.
A new light-emissive material, bis(3H-1,2,3-triazolo-[4,5-b]pyridine-3-ol)zinc (Zn(TAP)2), has been synthesized and characterized by FT-NMR, FT-IR, UV-Vis, and elemental analysis. The photoluminescence (PL) of Zn(TAP)2was measured from the DMF solution at 460 nm. The HOMO (6.5 eV) and LUMO (2.8 eV) energy levels of Zn(TAP)2were estimated from the measurement of cyclic voltammetry. The devices with structures of ITO/NPB/Zn(TAP)2/LiF/Al and ITO/NPB/Zn(TAP)2/Alq3/LiF/Al were constructed to investigate their electroluminescent (EL) performance. Zn (TAP)2is supposed to be a good emitting material in the EL device.
-Recently, new concept of energy systems such as microgrid, smart grid, supergrid, and energy network has been introducing. In this paper, the concept of the centralized micro-energy network, which is an energy community of a building group without district heating system, is introduced. In addition, a mathematical model for optimal operation of the micro-energy network as a main function of an energy management system (EMS) for the micro-energy network is proposed. In order to show the validation, the proposed model is tested through the simulation and analyzed.
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