Identifying and examining geological processes that have occurred in sediment‐starved trenches of ancient non‐accretionary subduction zones exposed on land are still challenging, because such style of subduction is believed to leave scarce rock records. Our new geological mapping, petrography of coarse clastic rocks, radiolarian and zircon U–Pb dating of the Shiriya accretionary complex in Northeast Japan suggest that the younger parts (Sr1 unit) of the complex formed in a sediment‐starved trench. The key observation is that debris derived from the inner trench slope directly overlies pelagic chert in many sections where trench turbidites are lacking. A significant mass of turbidites occurring in other sections are also considered to represent distal facies of the debrites from the adjacent inner trench slope, rather than normal trench‐fill turbidites directly supplied from the continental landmass. These recycled materials from the inner trench slope comprised an imbricate frontal accretionary wedge, together with pelagic siliceous deposits of ocean floor origin. This accretionary wedge of debrite origin suggests that mass wasting on inner slopes of sediment‐starved trenches does not always result in tectonic erosion (removal of materials from the upper plate), but results in material recycling to reconstruct a new frontal accretionary wedge. The spatial dimensions of the recycling cell may be one of the critical differences between accretionary and non‐accretionary margins. Recycled continental materials transported by turbidites from remote landmasses construct frontal wedges in accretionary margins, whereas mass wasting on adjacent slopes and re‐accretion at the trench recycle continental materials in non‐accretionary margins. The transition from an accretionary to non‐accretionary (i.e. sediment‐starved) trench detected in the Shiriya Complex potentially records tectonic response of the inner trench slope to increased friction along the subduction interface.

Aims-To clarify the significance of apoptosis in the progression of uterine cervical neoplasias, including cervical intraepithelial neoplasia (CIN), microinvasive carcinoma (MIC), and invasive squamous cell carcinoma (ISCC)

These results suggest that bone thickness measurements of the RGF by 3DX imaging was effective.

Aims-To clarify the role of human papillomavirus (HPV) infection in the development of papilloma, dysplasia, squamous cell carcinoma, and basal cell epithelioma arising from the eyelids, including the tunica conjunctiva palpebrum (conjunctiva), its junction to epidemis of eyelid skin (junction), and eyelid skin. Methods-Sixteen cases ofpapilloma, four of dysplasia, four of squamous cell carcinoma, and 12 of basal cell epithelioma were examined using formalin fixed and paraffin embedded samples. Detection of HPV-DNA was performed by PCR-RFLP and in situ hybridisation (ISH) methods. Results-HPV-16 was detected in 12/16 papillomas (75%), 2/4 dysplasias (50%), and 114 squamous cell carcinomas (25%) but in none of the basal cell epitheliomas. No other HPV subtypes were found. ISH assay showed positive signals in only two cases ofdysplasia and squamous cell carcinoma. The mean age ofHPV-16 positive dysplasia and squamous cell carcinoma cases (81.7 years) was significantly higher than that of HPV-16 positive papilloma cases (p<0.01).Conclusions-Based on the presence of HPV-16 in both benign and malignant lesions and the age distribution, it seems likely that HPV-16 alone may be incapable of causing development of conjunctival and junctional dysplasia and squamous cell carcinoma, and that any correlation between the papilloma-squamous cell carcinoma sequence and HPV infection may be due to rare events.(J Clin Pathol 1995;48:1106-1 1 10)

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We present a case of pleurodesis by intrapleural injection of OK-432 for the treatment of fetal chylothorax at an early gestational age. OK-432 injection achieved rapid and effective control of pleural effusion with no adverse effects.

Radiotherapy has been found to be valuable for the control and eradication of local foci in various malignant tumors. The abscopal effect is determined as a systemic antitumor response at a distance from the irradiation site invoked by local irradiation. We herein present an extremely rare case of breast cancer in a 64-year-old woman, in whom the abscopal effect was observed after radiotherapy induced an antitumor response in all metastatic lesions, without any combination therapy. The patient was admitted to our hospital complaining of a breast mass and pain at the left hip, and was diagnosed with breast cancer with multiple bone, lung and lymph node metastases. She received treatment with local radiotherapy delivered to the breast tumor and some of the bone metastases but did not receive chemotherapy due to her poor performance status. However, 10 months after radiotherapy, spontaneous regression was observed, not only within the irradiated field, but also in the non-irradiated areas. All signs of cancer throughout the body disappeared, and the patient's performance status drastically improved. To the best of our knowledge, there have been no reports of advanced breast cancer cases in which the abscopal effect was observed after radiation monotherapy; therefore, this case report is extremely rare and highly valuable.

HighlightsNeuroendocrine tumors of the extrahepatic bile ducts are extremely rare neoplasms.They most commonly occur in young females and usually present with painless jaundice.Preoperative diagnosis is difficult because the findings are similar to other biliary malignancies.Surgical resection is considered to be the only curative treatment.