The purpose of this study is to confirm the hypocalciuric effect of rice bran experimentally and clinically. Urinary calcium excretion and its absorption in the intestine were reduced significantly by rice bran or phytin in rats fed high calcium diets, while there were no significant decreases with a low calcium diet. For the clinical study 70 patients with idiopathic hypercalciuria were treated with rice bran (10 gm. twice daily) for 1 month to 3 years. In almost all patients rice bran caused a significant decrease in urinary calcium excretion, which was maintained during treatment. Evidence of stones has decreased clearly among patients treated with rice bran for 1 to 3 years, although this might be a halfway judgment of the long-term treatment. We suggest that phytin should be the most effective substance to reduce the intestinal absorption of calcium and that rice bran treatment should be effective for prevention of recurrent urinary stone disease.
We report on the efficacy of rice bran in hypercalciuric patients with urinary calculous disease. After the administration of defatted rice bran at a dosage of 20 gm. daily for 4 weeks urinary calcium excretion was reduced significantly from 402 plus or minus 102 to 291 plus or minus 123 mg. per 24 hours. In 6 patients who showed a reduction of urinary calcium excretion an increase in urinary calcium excretion was observed 4 weeks after stopping the administration. All 7 patients who previously received defatted rice bran were given processed or rice bran free of phytin at a dosage of 20 gm. daily. The value of urinary calcium excretion increased again during the administration of processed rice bran but was less marked than that of the preceding 6 patients. Although it is interesting to debate whether the influence of rice bran on the urinary calcium excretion depends on the action of phytin or of other constituents defatted rice bran should be effective in reducing urinary excretion of calcium. These results would come up to the expectations of the patients with recurrent urinary calculous disease.
Uterus didelphys with unilateral imperforate vagina is rare. Interestingly, in all reported cases in which the urinary tract was investigated renal agenesis was found on the side of the obstructed hemivagina. We report 2 cases of this unusual and interesting condition, and review the embryogenesis of müllerian duct abnormalities associated with renal agenesis, as well as the clinical findings, diagnosis and management. We stress the importance of prompt and accurate diagnosis, and treatment as a means to avoid unnecessary surgical procedures.
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