Rice Bran Treatment for Patients with Hypercalciuric Stones: Experimental and Clinical Studies

Ohkawa, Tadashi; Ebisuno, Shoichi; Kitagawa, Michio; Morimoto, Shigeyoshi; Miyazaki, Yoshihisa; Yasukawa, Shu

doi:10.1016/s0022-5347(17)50065-8

Cited by 69 publications

(33 citation statements)

References 18 publications

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“…Reduced phytate intake may be among the causes for the increased incidence of renal stones in industrialized countries (203). Henneman et al (206) used pure Na-phytate, and Ohkawa et al (207) used a diet containing high phytate concentration for the treatment of hypercalciuria and kidney stones. Since, in addition to above mentioned effects of phytic acid, it has been presented that IP6 may be useful in the management of HIV infection and associated immunodeficiency-related problems (111), the health effects presently associated with phytic acid appear to be as complex and numerous as those associated with dietary fibre.…”

Section: Anticancer Functions Of Myoinositol Phosphatesmentioning

confidence: 99%

Myoinositol Phosphates: Analysis, Content in Foods and Effects in Nutrition

Plaami¹

1997

LWT - Food Science and Technology

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Section: Anticancer Functions Of Myoinositol Phosphatesmentioning

confidence: 99%

Myoinositol Phosphates: Analysis, Content in Foods and Effects in Nutrition

Plaami¹

1997

LWT - Food Science and Technology

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“…The inhibitory effect of phytic acid on the amount of calcium excreted with urine was also found in experiments on rats fed a diet rich in this element (Ohkawa et al, 1984).…”

mentioning

confidence: 67%

Phytic acid - its influence on organism

Szkudelski¹

1997

J. Anim. Feed Sci.

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Phytic acid is found in the grains and seeds of many plants. Its presence in the diet may restrict the absorption of many major and trace elements from the digestive tract. The interactions of this compound with intestinal digesta compounds can reduce protein and starch digestibility. This leads to reduced nitrogen retention and causes a milder rise in glycemia during absorptive phase. Phytic acid also has antineoplastic properties, can prevent renal stone formation and some heart diseases. This compound is synthesized in mammalian tissues and its ability to bind specifically with some cellular proteins has been demonstrated.In this paper an outline of the most important metabolic effects of phytic acid is presented. It is also attempted to explain some of the mechanisms of its action based on data from the literature. KEY WORDS: phytic acid, metabolismPhytic acid (inositol hexaphosphosphoric acid) is found in many vegetable products used in the nutrition of animals and consumed by humans. The grain and seeds of certain plants, and their products such as wheat bran, are particularly rich in this compound. The phytic acid content in grain and seeds differs considerably, and can reach a maximum of about 2% dry weight (Reddy, 1992).The interference of phytic acid in metabolic processes begins even in the digestive tract, when it reacts with components of the intestinal contents.The most frequently observed consequence of the presence of phytic acid is inhibition of the absorption of many major and trace elements from the digestive

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“…However, there are other factors to consider such as bioavailability of the dietary oxalate, and nutritional factors such as dietary fibre and phytate. Some studies have shown that dietary phytic acid (James et al, 1978;Jahnen et al, 1992) could reduce the intestinal absorption of calcium by binding calcium in the gastrointestinal tract (Ohkawa et al, 1983(Ohkawa et al, , 1984Gleeson et al, 1990;Ebisuno et al, 1991). Consequently, more free oxalate could be available to be absorbed.…”

Section: Discussionmentioning

confidence: 99%

Influence of a low- and a high-oxalate vegetarian diet on intestinal oxalate absorption and urinary excretion

2007

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Objective: To compare quantitatively the effect of a low-and a high-oxalate vegetarian diet on intestinal oxalate absorption and urinary excretion. Subjects and methods: Eight healthy volunteers (three men and five women, mean age 28.676.3) were studied. Each volunteer performed the [ 13 C 2 ]oxalate absorption test thrice on a low-oxalate mixed diet, thrice on a low-oxalate vegetarian diet and thrice on a high-oxalate vegetarian diet. For each test, the volunteers had to adhere to an identical diet and collect their 24-h urines. In the morning of the second day, a capsule containing [ 13 C 2 ]oxalate was ingested. Results: On the low-oxalate vegetarian diet, mean intestinal oxalate absorption and urinary oxalate excretion increased significantly to 15.872.9% (P ¼ 0.012) and 0.41470.126 mmol/day (P ¼ 0.012), compared to the mixed diet. On the highoxalate vegetarian diet, oxalate absorption (12.574.6%, P ¼ 0.161) and urinary excretion (0.34070.077 mmol/day, P ¼ 0.093) did not change significantly, compared to the mixed diet. Conclusions: A vegetarian diet can only be recommended for calcium oxalate stone patients, if the diet (1) contains the recommended amounts of divalent cations such as calcium and its timing of ingestion to a meal rich in oxalate is considered and (2) excludes foodstuffs with a high content of nutritional factors, such as phytic acid, which are able to chelate calcium.

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Rice Bran Treatment for Patients with Hypercalciuric Stones: Experimental and Clinical Studies

Cited by 69 publications

References 18 publications

Myoinositol Phosphates: Analysis, Content in Foods and Effects in Nutrition

Myoinositol Phosphates: Analysis, Content in Foods and Effects in Nutrition

Phytic acid - its influence on organism

Influence of a low- and a high-oxalate vegetarian diet on intestinal oxalate absorption and urinary excretion

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