A unique semibatch crystallization process, coupling with a high-speed rotor-stator device, was developed for generation and control of fine particles. The key underlying mechanism of this process is controlled secondary nucleation under a high shear environment during crystallization, in contrast to the conventional particle breakage mechanism, i.e., milling, after the crystallization. A recycle mode operation is employed to control the residence time of the batch in the high shear domain so as to ensure the scalability of this process. In this work, the operational sensitivity to the supersaturation and particle size were first explored in the laboratory. Based on the results of the laboratory investigation, this process was successfully demonstrated in multiple 1000-L pilot scale production batches. The practical issues for the large scale operation are also illustrated.

We investigated 60 cases of so-called denture fibroma, most of which occurred in women in their 50s to 70s. The most commonly affected areas were the upper alveolar ridge and the bottom of the alveolabial sulcus, and most of the prostheses responsible were complete dentures. Elevated and tumor-like lesions were most frequent. Histopathologically, about 60% of the lesions were of the fibromatous type. Degeneration and inflammation of the salivary glands were identified in one third of cases.

Beacon Diagnostics Pvt. Ltd is well equipped, independent manufacturing facility as per WHO guidelines & U.S.F.D.A regulations. Beacon is a Research & Development Oriented Company. Their R&D sections are doing continuous research in Diagnostic Products at Navsari, Gujarat, India. Beacon Diagnostics Pvt. Ltd has faced problems in dilute process of chemicals, the mixing of chemicals in dilute process does not result into the homogenous mixture. It also causes difference in pH values at various levels for same chemical mixture in tank. This dilute process is t ime consuming. This project intend to modify the agitator to make the mixture homogenous so that we can get equal pH value at all levels for sa me chemical mixture in Stirling tank. Homogeneous mixture and required pH value of mixture is achieved by modifying industrial agitator .In this project, we modified agitator by increasing Number of Impeller Blade, using of Agitator with different shapes of blades, changing position and orientation of agitator. Result shows that By changing position and orientation of agitator at bottom of stirred tank with 45 0 Angle homogeneous mixture with 7.1 pH value at upper side and bottom side of stirred tank is received. Time of dilute process is reduced to 30 minutes from 2 hour.

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