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Photoswitchable fluorescent polymeric nanoparticles with AIE-based fluorogens as FRET donors were prepared for rewritable fluorescence patterning and intracellular dual-color imaging.

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FRET-based fluorescent polymer dots (FPD) with good membrane permeability have been developed for ratiometric imaging of lysosomal HClO in living cells.

The AIE dots (AIED) with superior sensor properties have been developed for selective imaging of lysosomal H2S in living cells.

A novel lysosome-targetable ratiometric AIE nanoprobe was rationally designed and synthesized for sensing of endogenous HClO levels in live cells.

In this study, amphiphilic diblock copolymers were designed and synthesized via the incorporation of reversible additionfragmentation chain transfer radical polymerization (RAFT) and a subsequent grafting technique. Subsequently, Hg 2+ -sensitive water-soluble fluorescent polymeric micelles (FNs) were prepared by a reprecipitation strategy. The spectroscopic characteristics demonstrate that the fluorescein isothiocyanate (FITC) was successfully linked into the polymer. Due to the promoted reaction of desulfurization cyclization by Hg 2+ , the fluorescence of fluorescein in FNs was obviously quenched. The as-prepared FNs showed admirable Hg 2+ -sensitivity (detection limit: 54 nM), excellent water-solubility and high selectivity. In addition, FNs were successfully used to determine Hg 2+ in blood serum. We expected that the as-prepared FNs could perform potential applications in imaging, sensing, and bioanalytic chemistry.

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