In this study, we successfully developed novel tumor homing-penetrating peptide-functionalized drug-loaded phase-transformation nanoparticles (tLyP-1-10-HCPT-PFP NPs) for low intensity focused ultrasound (LIFU)-assisted tumor ultrasound molecular imaging and precise therapy. With the nanoscale particle size, tLyP-1-10-HCPT-PFP NPs could pass through the tumor vascular endothelial cell gap. Induced by tLyP-1 peptide with targeting and penetrating efficiency, tLyP-1-10-HCPT-PFP NPs could increase tumor accumulation and penetrate deeply into the extravascular tumor tissue, penetrating through extracellular matrix and the cellular membrane to the cytoplasm. With LIFU assistance, tLyP-1-10-HCPT-PFP NPs could phase-transform into microbubbles and enhance tumor ultrasound molecular imaging for tumor diagnosis. Furthermore, after further irradiation by LIFU, an intracellular "explosion effect" caused by acoustic droplet vaporization, ultrasound targeted microbubble destruction, and release of 10-HCPT could realize physicochemical synergistic antitumor therapy.

The premature leakage of anticancer drugs during blood circulation may the damage immune system, normal cells, and tissues. Constructing targeted nanocarriers with pH, glutathione, and NIR triple-responsive property can effectively avoid the leakage of anticancer drugs before they arrive at the targeted site. In this paper, magnetic hollow porous carbon nanoparticles (MHPCNs) were successfully fabricated as nanocarrier. Poly(γ-glutamic acid) was used to cap the pores of MHPCNs. The photothermal conversion property of carbon and iron oxide (FeO) nanomaterials was utilized to perform photothermal therapy to overcome multidrug-resistance produced by chemotherapy. The biodistribution of nanoparticles was investigated by magnetic resonance imaging. Experiments in vivo confirm the efficient accumulations of nanoparticles at tumor sites. Meanwhile, tumor growth was effectively inhibited via synergistic photothermal/chemotherapy with minimal side effects.

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A certain gap spacing between adjacent vehicles is usually inevitable in wind tunnel force tests of high-speed trains under no crosswind, which may affect the wind tunnel test results. Thus, to understand the influence of gap spacings on the train aerodynamics, the aerodynamic drag, pressure distributions and airflow structures of 1/8th-scale high-speed train models with gap spacings of 0, 5, 8, 10, 20, and 30 mm were studied using RANS based on SST k-ω turbulence model. The simulation method was verified by the wind tunnel experiment data. The results show that the gap spacing significantly affects the airflow structure around inter-car gap and aerodynamic resistances of train models. For the high-speed train model scaled at 1/8th at zero yaw, compared with gap spacing of 0 mm, the gap spacings lead to a significant reduction in the aerodynamic drag of the head car and an increase in that of the tail car, whereas which of the middle car is not significant. The maximum difference of the drag coefficient of the entire train model is smaller than 2.0%. When the gap spacing does not exceed 8 mm, the discrepancies of the drag coefficients of three cars are within 6.15%.