Triple Stimuli-Responsive Magnetic Hollow Porous Carbon-Based Nanodrug Delivery System for Magnetic Resonance Imaging-Guided Synergistic Photothermal/Chemotherapy of Cancer

Wu, Fan; Zhang, Ming; Lu, Hanwen; Liang, Dong; Huang, Yaliang; Xia, Yonghong; Hu, Yuqing; Hu, Shengqiang; Wang, Jianxiu; Yi, Xinyao; Zhang, Jun

doi:10.1021/acsami.8b07213

Cited by 85 publications

(52 citation statements)

References 55 publications

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“…Earlier studies indicate that intraperitoneal administration of silver NPs induces cytoplasmic changes in liver and kidney tissues43 while intravenously administered silver NPs accumulate in different organs, including liver, kidney, spleen, brain and lungs 25. Another recent investigation demonstrated that magnetic hollow porous carbon NPs (MHPCNs) are primarily deposited in spleen, lung and liver 44…”

Section: Discussionmentioning

confidence: 99%

<p>Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats</p>

Gaharwar¹,

Meena²,

Rajamani³

2019

IJN

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IntroductionNanoparticles are used worldwide because of their unique properties, with large-scale application in various fields, such as medicine, cosmetics and industries. In view of their widespread use, the potential adverse effects of nanoparticles have become a significant cause for concern, in terms of not only human health and safety but also the environment. The present investigation focused on establishing the bioaccumulation patterns and ultrastructural changes induced by retained iron oxide nanoparticles (IONPs) in various target organs of rats.MethodsTwenty-four male Wistar rats were randomly divided into four groups. Experimental animals were intravenously administered different doses of IONPs (7.5 mg/kg, 15 mg/kg and 30 mg/kg) once in a week for 4 weeks. Urine and feces samples were collected on a daily basis to assess nanoparticle clearance and analyzed via atomic absorption spectroscopy (AAS). At the end of the experiment, rats were euthanized and different organs, including spleen, liver, kidney, lung, heart, testis and brain, were dissected. Bioaccumulation of iron in organs and ultrastructural changes induced by IONPs were determined.ResultsThe maximal concentration of iron was detected in spleen and minimal concentration in the brain. The level of iron accumulation in organs was as follows: spleen>blood>liver>kidney>lung>heart>testis>brain. The excretion profile in urine revealed maximum excretion on the day following administration that was maintained until day 28, whereas the iron content in feces remained high during the first three days after injection. A similar pattern was observed throughout the duration of the experiment. Ultrastructural alterations were detected in spleen, kidney, lung, heart, testis, brain and liver, indicative of cellular damage induced by accumulating nanoparticles in these organs.ConclusionIntravenous administration of IONPs results in ultrastructural changes and dose-dependent bioaccumulation in different organs of rats.

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Section: Discussionmentioning

confidence: 99%

<p>Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats</p>

Gaharwar¹,

Meena²,

Rajamani³

2019

IJN

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“…Carbon [139,140], gold [141], and upconversion nanoparticles (UCNPs) [142] were often utilized in NIR responsive drug carriers owing to their NIR absorption capacity. Lee and co-workers [139] fabricated the hollow mesoporous silica/carbon nanoparticles as a DOX carrier.…”

Section: Response To Near-infrared (Nir)mentioning

confidence: 99%

Hollow structures as drug carriers: Recognition, response, and release

Zhao

Yang

et al. 2021

Nano Res.

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Hollow structures have demonstrated great potential in drug delivery owing to their privileged structure, such as high surface-to-volume ratio, low density, large cavities, and hierarchical pores. In this review, we provide a comprehensive overview of hollow structured materials applied in targeting recognition, smart response, and drug release, and we have addressed the possible chemical factors and reactions in these three processes. The advantages of hollow nanostructures are summarized as follows: hollow cavity contributes to large loading capacity; a tailored structure helps controllable drug release; variable compounds adapt to flexible application; surface modification facilitates smart responsive release. Especially, because the multiple physical barriers and chemical interactions can be induced by multishells, hollow multishelled structure is considered as a promising material with unique loading and releasing properties. Finally, we conclude this review with some perspectives on the future research and development of the hollow structures as drug carriers.

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“…In the following year, Fang et al utilized graphene carbon dots to seal the pores, which also functioned as a robust PTT agent in the subsequent synergistic chemo/photothermal cervical cancer treatment. 80 A triple stimuli-response magnetic hollow porous carbon-based drug delivery system (MHPCNs–SS–PGA–FA/DOX) was developed by Wu et al 81 . The poly-γ-glutamic acid-capped shell of hollow NPs included an inner Fe 3 O 4 layer and a porous carbon outer layer.…”

Section: Photothermal-based Therapy For Cancer Treatmentmentioning

confidence: 99%

Advances in Hollow Inorganic Nanomedicines for Photothermal-Based Therapies

Chen¹,

Wang²,

Shen³

2021

IJN

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Nanotechnology has prompted the development of hollow inorganic nanomedicine. These medicines are now widely investigated as photothermal-based therapies for various diseases due to their high loading capacity, tuneable wavelength, relatively small size and low density. We begin this review with a brief introduction, followed by a summary of the development of imaging-guided photothermal therapy (PTT) for cancer treatment during the last three years (from 2017 to 2020). We then introduce the antibacterial effects of these medicines on some bacterial infections, in which the pathogenic bacteria can be killed by mild photothermal effects, ions and antibiotic release. Other diseases can also be treated using hollow inorganic photothermal agents. Specifically, we discuss the use of PTT for treating Alzheimer's disease, obesity and endometriosis. Finally, we share our perspectives on the current challenges and future prospects of using hollow inorganic materials in clinical PTT for various diseases.

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Triple Stimuli-Responsive Magnetic Hollow Porous Carbon-Based Nanodrug Delivery System for Magnetic Resonance Imaging-Guided Synergistic Photothermal/Chemotherapy of Cancer

Cited by 85 publications

References 55 publications

<p>Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats</p>

<p>Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats</p>

Hollow structures as drug carriers: Recognition, response, and release

Advances in Hollow Inorganic Nanomedicines for Photothermal-Based Therapies

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