The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption 1,2 . There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.

Non-confined MgH2 nanoparticles of 4–5 nm diameter enable reversible storage of hydrogen up to 6.7 wt% at 30 °C.

Room-temperature sodium−sulfur (RT Na−S) batteries are widely considered as one of the alternative energystorage systems with low cost and high energy density. However, the both poor cycle stability and capacity are two critical issues arising from low conversion kinetics and sodium polysulfides (NaPSs) dissolution for sulfur cathodes during the charge/discharge process. Herein, we report a highly stable RT Na−S battery cathode via building heterostructures in multichannel carbon fibers. The TiN-TiO 2 @MCCFs, fabricated by electrospinning and nitriding techniques, are loaded with the active material S, forming S/TiN-TiO 2 @MCCFs as the cathode in a RT Na−S battery. At 0.1 A g −1 , the cathode produces the capacity of more than 640 mAh g −1 within 100 cycles with a high Coulombic efficiency of nearly 100%. Even at 5 A g −1 , the battery still exhibites a capacity of 257.1 mAh g −1 after 1000 cycles. Combining structural and electrochemical analyses with the first-principles calculations reveals that the incorporation of the highly electrocatalytic activity of TiN with the powerful chemisorption of TiO 2 well stabilizes S and also alleviates the shuttle effects of polysulfides. This work with simple processes and low cost is expected to promote the further development and application of metal−S batteries.

No abstract