High-resolution images obtained in Hα with the new Swedish Solar Telescope at La Palma, Spain, have been used for studies of fine-scale threads in solar filaments. The widths of the thin threads are ≤0.3 arc sec. The fact that the width of the thinnest threads is comparable to the diffraction limit of the telescope of about 0.14 arc sec, at the wavelength of Hα, suggests that even thinner threads may exist. Assuming that the threads represent thin magnetic strings, we conclude that only a small fraction of these are filled with observable absorbing plasma, at a given time. The absorbing plasma is continuously flowing along the thread structures at velocities 15 ± 10 km s −1 , which suggests that the flows must be field-aligned. In one case where a bundle of thin threads appears to be rooted in the nearby photosphere, we find that the individual threads connects with intergranular, dark lanes in the photosphere. We do not find signs of typical network fields at the 'roots' of the fine threads, as normally evidenced by bright points in associated G-band images. It is suggested that filament threads are rooted in relatively weak magnetic fields.

From recent high resolution observations obtained with the Swedish 1-m Solar Telescope in La Palma, we detect swaying motions of individual filament threads in the plane of the sky. The oscillatory character of these motions are comparable with oscillatory Doppler signals obtained from corresponding filament threads. Simultaneous recordings of motions in the line-of-sight and in the plane of the sky give information about the orientation of the oscillatory plane. These oscillations are interpreted in the context of the magnetohydrodynamic theory. Kink magnetohydrodynamic waves supported by the thread body are proposed as an explanation of the observed thread oscillations. On the basis of this interpretation and by means of seismological arguments, we give an estimation of the thread Alfvén speed and magnetic field strength by means of seismological arguments.

High-resolution Hα filtergrams (0.2 ) obtained with the Swedish 1-m Solar Telescope resolve numerous very thin, thread-like structures in solar filaments. The threads are believed to represent thin magnetic flux tubes that must be longer than the observable threads. We report on evidence for small-amplitude (1 -2 km s −1 ) waves propagating along a number of threads with an average phase velocity of 12 km s −1 and a wavelength of 4 . The oscillatory period of individual threads vary from 3 to 9 minutes. Temporal variation of the Doppler velocities averaged over a small area containing a number of individual threads shows a short-period (3.6 minutes) wave pattern. These short-period oscillations could possibly represent fast modes in accordance with numerical fibril models proposed by Díaz et al. (Astron. Astrophys. 379, 1083, 2001. In some cases, it is clear that the propagating waves are moving in the same direction as the mass flows.

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The zinc-finger transcription factor Snail1 is inappropriately expressed in breast cancer and associated with poor prognosis. While interrogating human databases, we uncovered marked decreases in relapse-free survival of breast cancer patients expressing high Snail1 levels in tandem with wild-type, but not mutant, p53. Using a Snail1 conditional knockout model of mouse breast cancer that maintains wild-type p53, we find that Snail1 plays an essential role in tumour progression by controlling the expansion and activity of tumour-initiating cells in preneoplastic glands and established tumours, whereas it is not required for normal mammary development. Growth and survival of preneoplastic as well as neoplastic mammary epithelial cells is dependent on the formation of a Snail1/HDAC1/p53 tri-molecular complex that deacetylates active p53, thereby promoting its proteasomal degradation. Our findings identify Snail1 as a molecular bypass that suppresses the anti-proliferative and pro-apoptotic effects exerted by wild-type p53 in breast cancer.