Chalcone-1-deoxynojirimycin heterozygote (DC-5), a novel compound which was designed and synthesized in our laboratory for diabetes treatment, showed an extremely strong in vitro inhibitory activity on α-glucosidase in our previous studies. In the current research, its potential in vivo anti-diabetic effects were further investigated by integration detection and the analysis of blood glucose concentration, blood biochemical parameters, tissue section and gut microbiota of the diabetic rats. The results indicated that oral administration of DC-5 significantly reduced the fasting blood glucose and postprandial blood glucose, both in diabetic and normal rats; meanwhile, it alleviated the adverse symptoms of elevated blood lipid level and lipid metabolism disorder in diabetic rats. Furthermore, DC-5 effectively decreased the organ coefficient and alleviated the pathological changes of the liver, kidney and small intestine of the diabetic rats at the same time. Moreover, the results of 16S rDNA gene sequencing analysis suggested that DC-5 significantly increased the ratio of Firmicutes to Bacteroidetes and improved the disorder of gut microbiota in diabetic rats. In conclusion, DC-5 displayed a good therapeutic effect on the diabetic rats, and therefore had a good application prospect in hypoglycemic drugs and foods.
Key indicators: single-crystal X-ray study; T = 291 K; mean (C-C) = 0.006 Å; disorder in main residue; R factor = 0.049; wR factor = 0.088; data-to-parameter ratio = 14.5.In the title centrosymmetric complex, [Cu 2 (C 15 , the bridging Cu 2 Cl 2 ring, which is exactly planar by virtue of a crystallographic inversion center, has two different Cu-Cl distances. The dihedral angle between the pyridine and imidazole ring planes is 2.49 (4) . In the crystal structure, intermolecular O-HÁ Á ÁO hydrogen bonds link dimer molecules into a one-dimensional chain in the c-axis direction. The atoms of the isopropyl and ethyl groups are disordered over two sites with approximate occupancies of 0.75:0.25 and 0.5:0.5, respectively.
C-96 04. ATOMIC SCALE MECHANISMS AND CHEMICAL PROPERTIES 3.1 ~ [H(D) ••• o > 2.70 ~J, far outside the usual hydrogen bond range. Vibrational spectroscopic investigations on isotopically dilute CH and D) single crystals, measured at 295 K and 75 K, showed uncoupled 0-H(D) stretching frequencies in the range ~ = 2345-2665 (3145-3620) cm-1. According to the Badger-Bauer rule these frequencies would correspond to hydrogen bond energies of 5-40 kJ mol-1. Reasonable assignments of the observed frequencies to the individual hydrogen bonds could be made. For the approximately linear 0-H(D) ••• S type bonds with H(D) ••• s = 2.35 R
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