Background: Selenoproteins are important enzymes involved in antioxidant defense, redox homeostasis, and signaling. Results: We report that, in HEK293 cells, several selenoproteins are selectively up-regulated in response to H 2 O 2 treatment. Conclusion: We identify a novel translational control mechanism for selenoproteome regulation. Significance: Antioxidant selenoproteins are regulated by oxidative stress when selenium is limiting.

Background: Selenoproteins are important enzymes for antioxidant defense, redox homeostasis, and redox signaling. Results: We report that, in WI-38 human fibroblasts, replicative senescence is controlled by selenium levels and selectively modulates selenoprotein expression. Conclusion: Our data indicate that the selenoproteome is regulated at the translational and mRNA levels in WI-38 cells. Significance: We have characterized a strong interplay between selenium levels, selenoprotein expression, and replicative senescence.

IRF5 haplotypes are more informative than single markers, suggesting that they could be helpful for risk stratification of SSc patients. Our study provides further evidence of a key role of IRF5 in SSc severity.