Background: Selenoproteins are important enzymes involved in antioxidant defense, redox homeostasis, and signaling. Results: We report that, in HEK293 cells, several selenoproteins are selectively up-regulated in response to H 2 O 2 treatment. Conclusion: We identify a novel translational control mechanism for selenoproteome regulation. Significance: Antioxidant selenoproteins are regulated by oxidative stress when selenium is limiting.
Background: Selenoproteins are important enzymes for antioxidant defense, redox homeostasis, and redox signaling. Results: We report that, in WI-38 human fibroblasts, replicative senescence is controlled by selenium levels and selectively modulates selenoprotein expression. Conclusion: Our data indicate that the selenoproteome is regulated at the translational and mRNA levels in WI-38 cells. Significance: We have characterized a strong interplay between selenium levels, selenoprotein expression, and replicative senescence.
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