Intellectual development of offspring of diabetic mothers. Acta Pzdiatr 1996;85: 1 192-6. Stockholm. ISSN 0803-5253 We prospectively evaluated the intellectual development of 33 children who were born to 33 diabetic Japanese mothers and compared them to 34 children born to non-diabetic mothers (controls) during the same period at Kurume University Hospital between 1987and i 989. Birthweight, maternal ageand the infant's age at the time of intelligence testing did not differ significantly between the offspring of diabetic mothers (ODMs) and controls. Tanaka-Binet intelligence scores were significantly lower in the ODMs at 3 years of age than in controls (98.4 f 17.4 versus 113.4 f 15.3) (p = 0.0005). No correlation was found between IQ and maternal haemoglobin A,, levels during pregnancy. Maternal age and infant IQ were inversely correlated in ODMs ( p = 0.0298, r = -0.3984), but no such correlation was demonstrated in the controls. The results indicated that the ODMs may show a poorer intellectual development than those of non-diabetic mothers. Haemoglobin A,,. IQ, matema/ age. offspring of diabetic mothers y Yamashira,

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