Intellectual development of offspring of diabetic mothers

Abstract

Intellectual development of offspring of diabetic mothers. Acta Pzdiatr 1996;85: 1 192-6. Stockholm. ISSN 0803-5253 We prospectively evaluated the intellectual development of 33 children who were born to 33 diabetic Japanese mothers and compared them to 34 children born to non-diabetic mothers (controls) during the same period at Kurume University Hospital between 1987and i 989. Birthweight, maternal ageand the infant's age at the time of intelligence testing did not differ significantly between the offspring of diabetic mothers (ODMs) and controls. Tanaka-Binet intelligence scores were significantly lower in the ODMs at 3 years of age than in controls (98.4 f 17.4 versus 113.4 f 15.3) (p = 0.0005). No correlation was found between IQ and maternal haemoglobin A,, levels during pregnancy. Maternal age and infant IQ were inversely correlated in ODMs ( p = 0.0298, r = -0.3984), but no such correlation was demonstrated in the controls. The results indicated that the ODMs may show a poorer intellectual development than those of non-diabetic mothers. Haemoglobin A,,. IQ, matema/ age. offspring of diabetic mothers y Yamashira,

Diabetes in Pregnancy and Childhood Cognitive Development: A Systematic Review

“…It has been suggested by some investigators that offspring born to either mothers with PDM or GDM are more likely to have poorer cognitive and language development than those born to nondiabetic mothers. [28][29][30][31][32][33] However, other investigators have either found no such associations 17,18,20,22 or report contradictory findings. 23 To the best of our knowledge, systematically synthesized information on the associations between maternal diabetes during pregnancy and offspring's cognitive development, particularly in childhood, is lacking.…”

“…Therefore, we included Nelson et al 32 (ie, better sample size and relatively recent) and Townsend et al 22 (ie, cognitive development was measured at the age of 4 years by using the Wechsler Intelligence Scale for Children) in the review. Overall, 14 studies [16][17][18][19][20][21][22][23][28][29][30][31][32][33] were eligible for the present review.…”

“…In addition, mixed results have been reported, with null or positive associations between different measures of maternal metabolic control and diverse measures of cognitive ability. 26,29,33,39 Even with well-controlled maternal diabetes, offspring's cognitive development has been found to be significantly impaired. 19,31 Regardless of maternal metabolic control, in our systematic review, 1 study 16 fully adjusted for potential confounders with relatively good power, as well as other studies 19,21,[29][30][31][32][33] that partially adjusted for potential confounders, reported significantly impaired cognitive development in offspring born to mothers with either PDM or GDM.…”

“…Similarly, Yamashita et al 33 found significantly lower TanakaBinet IQ scores in 15 OPDM (98 ± 17) compared with 15 control subjects (113 ± 15; P < .0001). However, both studies failed to account for any potential confounder.…”

“…In addition to low overall scores, the following quality concerns were observed: one-half of the studies reported unadjusted results; in all studies (except 1 report 30 ) the population was obtained from unrepresentative populations, mainly from hospital facilities; and 7 of 14 studies 16,17,22,23,29,31,33 reported the use of standard cognitive development assessment tools but failed to provide or report blind assessment.…”